KEGG   ENZYME: 1.14.16.3Help
Entry
EC 1.14.16.3                Enzyme                                 

Name
anthranilate 3-monooxygenase;
anthranilate 3-hydroxylase;
anthranilate hydroxylase;
anthranilic hydroxylase;
anthranilic acid hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
anthranilate + tetrahydrobiopterin + O2 = 3-hydroxyanthranilate + dihydrobiopterin + H2O [RN:R01816]
Reaction(KEGG)
Substrate
anthranilate [CPD:C00108];
tetrahydrobiopterin [CPD:C00272];
O2 [CPD:C00007]
Product
3-hydroxyanthranilate [CPD:C00632];
dihydrobiopterin [CPD:C00268];
H2O [CPD:C00001]
Comment
Requires Fe2+.
History
EC 1.14.16.3 created 1972
Pathway
Tryptophan metabolism
Reference
1  [PMID:5789774]
  Authors
Jequier E, Robinson DS, Lovenberg W, Sjoerdsma A.
  Title
Further studies on tryptophan hydroxylase in rat brainstem and beef pineal.
  Journal
Biochem. Pharmacol. 18 (1969) 1071-81.
  Organism
Rattus norvegicus, Bos taurus
Reference
2
  Authors
Nair, P.M. and Vaidyanathan, C.S.
  Title
Anthranilic acid hydroxylase from Tecoma stans.
  Journal
Biochim. Biophys. Acta 110 (1965) 521-531.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-79-4

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