KEGG   ENZYME: 1.14.16.5Help
Entry
EC 1.14.16.5                Enzyme                                 

Name
alkylglycerol monooxygenase;
glyceryl-ether monooxygenase;
glyceryl-ether cleaving enzyme;
glyceryl ether oxygenase;
glyceryl etherase;
O-alkylglycerol monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase
Reaction(IUBMB)
1-O-alkyl-sn-glycerol + tetrahydrobiopterin + O2 = 1-O-(1-hydroxyalkyl)-sn-glycerol + dihydrobiopterin + H2O [RN:R04044]
Reaction(KEGG)
Substrate
1-O-alkyl-sn-glycerol [CPD:C02773];
tetrahydrobiopterin [CPD:C00272];
O2 [CPD:C00007]
Product
1-O-(1-hydroxyalkyl)-sn-glycerol;
dihydrobiopterin [CPD:C00268];
H2O [CPD:C00001]
Comment
The enzyme cleaves alkylglycerols, but does not cleave alkenylglycerols (plasmalogens). Requires non-heme iron [7], reduced glutathione and phospholipids for full activity. The product spontaneously breaks down to form a fatty aldehyde and glycerol.
History
EC 1.14.16.5 created 1972 as EC 1.14.99.17, transferred 1976 to EC 1.14.16.5, modified 2010
Orthology
K15537  
alkylglycerol monooxygenase
Genes
HSA: 
392636(AGMO)
PTR: 
463272(AGMO)
PPS: 
100988512(AGMO)
GGO: 
101133058(AGMO)
PON: 
100438998(AGMO)
NLE: 
100598360(AGMO)
MCC: 
709963(AGMO)
MCF: 
102140354(AGMO)
CSAB: 
103226453(AGMO)
RRO: 
104668141(AGMO)
CJC: 
100393907(AGMO)
SBQ: 
101046685(AGMO)
MMU: 
319660(Agmo)
RNO: 
362732(Agmo)
CGE: 
100752746(Agmo)
NGI: 
103726803(Agmo)
HGL: 
106008946(Agmo)
OCU: 
100339522(AGMO)
TUP: 
102487435(AGMO)
CFA: 
475247(AGMO)
AML: 
UMR: 
103658833(AGMO)
FCA: 
101082991(AGMO)
PTG: 
102953129(AGMO)
BTA: 
613658(AGMO)
BOM: 
102287910(AGMO)
PHD: 
102316332(AGMO)
CHX: 
102177125(AGMO)
OAS: 
101103313(AGMO)
SSC: 
100513371(AGMO)
CFR: 
102508044(AGMO)
BACU: 
103007090(AGMO)
LVE: 
103084449(AGMO)
ECB: 
100052771(AGMO)
MYB: 
102253210(AGMO)
MYD: 
102767015(AGMO)
PALE: 
102888896(AGMO)
LAV: 
100659232(AGMO)
MDO: 
100022353(AGMO)
SHR: 
100934114(AGMO)
OAA: 
100080816(AGMO)
GGA: 
772374(AGMO)
MGP: 
100545428(AGMO)
CJO: 
107309232(AGMO)
APLA: 
101801837(AGMO)
TGU: 
100223605(AGMO)
GFR: 
102041091(AGMO)
FAB: 
101808659(AGMO)
PHI: 
102106287(AGMO)
CCW: 
104689135(AGMO)
FPG: 
101915982(AGMO)
FCH: 
102045933(AGMO)
CLV: 
102091863(AGMO)
AAM: 
106483529(AGMO)
ASN: 
102377527(AGMO)
AMJ: 
102576260(AGMO)
PSS: 
102463873(AGMO)
CMY: 
102934438(AGMO)
ACS: 
100564327(agmo)
PBI: 
103059739(AGMO)
XTR: 
496770(agmo)
DRE: 
405819(agmo)
TRU: 
101062615(agmo)
MZE: 
101470736(agmo)
OLA: 
101160098(agmo)
XMA: 
102222346(agmo)
SASA: 
LCM: 
102351412(AGMO)
CMK: 
103182639(agmo)
BFO: 
CIN: 
SPU: 
SKO: 
AME: 
413590(GB18268)
BIM: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
DPX: 
CEL: 
CELE_BE10.2(agmo-1)
CBR: 
LOA: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
TAD: 
AQU: 
CVR: 
APRO: 
SRE: 
DDI: 
DPP: 
DFA: 
ACAN: 
SMIN: 
v1.2.017513.t1(symbB.v1.2.017513.t1)
GTT: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:6840084]
  Authors
Ishibashi T, Imai Y.
  Title
Solubilization and partial characterization of alkylglycerol monooxygenase from rat liver microsomes.
  Journal
Eur. J. Biochem. 132 (1983) 23-7.
Reference
2  [PMID:4383918]
  Authors
Pfleger RC, Piantadosi C, Snyder F.
  Title
The biocleavage of isomeric glyceryl ethers by soluble liver enzymes in a variety of species.
  Journal
Biochim. Biophys. Acta. 144 (1967) 633-48.
Reference
3  [PMID:4355017]
  Authors
Snyder F, Malone B, Piantadosi C.
  Title
Tetrahydropteridine-dependent cleavage enzyme for O-alkyl lipids: substrate specificity.
  Journal
Biochim. Biophys. Acta. 316 (1973) 259-65.
Reference
4  [PMID:4402391]
  Authors
Soodsma JF, Piantadosi C, Snyder F.
  Title
Partial characterization of the alkylglycerol cleavage enzyme system of rat liver.
  Journal
J. Biol. Chem. 247 (1972) 3923-9.
Reference
5  [PMID:14247652]
  Authors
TIETZ A, LINDBERG M, KENNEDY EP.
  Title
A NEW PTERIDINE-REQUIRING ENZYME SYSTEM FOR THE OXIDATION OF GLYCERYL ETHERS.
  Journal
J. Biol. Chem. 239 (1964) 4081-90.
Reference
6  [PMID:9436181]
  Authors
Taguchi H, Armarego WL
  Title
Glyceryl-ether monooxygenase [EC 1.14.16.5]. A microsomal enzyme of ether lipid metabolism.
  Journal
Med. Res. Rev. 18 (1998) 43-89.
Reference
7  [PMID:19007315]
  Authors
Watschinger K, Keller MA, Hermetter A, Golderer G, Werner-Felmayer G, Werner ER
  Title
Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal  ion and tetrahydrobiopterin dependence.
  Journal
Biol. Chem. 390 (2009) 3-10.
Reference
8  [PMID:17303893]
  Authors
Werner ER, Hermetter A, Prast H, Golderer G, Werner-Felmayer G
  Title
Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay.
  Journal
J. Lipid. Res. 48 (2007) 1422-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-82-9

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