KEGG   ENZYME: 1.14.16.5Help
Entry
EC 1.14.16.5                Enzyme                                 
Name
alkylglycerol monooxygenase;
glyceryl-ether monooxygenase;
glyceryl-ether cleaving enzyme;
glyceryl ether oxygenase;
glyceryl etherase;
O-alkylglycerol monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase
Reaction(IUBMB)
1-O-alkyl-sn-glycerol + tetrahydrobiopterin + O2 = 1-O-(1-hydroxyalkyl)-sn-glycerol + dihydrobiopterin + H2O [RN:R04044]
Reaction(KEGG)
Substrate
1-O-alkyl-sn-glycerol [CPD:C02773];
tetrahydrobiopterin [CPD:C00272];
O2 [CPD:C00007]
Product
1-O-(1-hydroxyalkyl)-sn-glycerol;
dihydrobiopterin [CPD:C00268];
H2O [CPD:C00001]
Comment
The enzyme cleaves alkylglycerols, but does not cleave alkenylglycerols (plasmalogens). Requires non-heme iron [7], reduced glutathione and phospholipids for full activity. The product spontaneously breaks down to form a fatty aldehyde and glycerol.
Orthology
K15537  
alkylglycerol monooxygenase
Genes
HSA: 
392636(AGMO)
PTR: 
463272(AGMO)
PPS: 
100988512(AGMO)
GGO: 
101133058(AGMO)
PON: 
100438998(AGMO)
MCC: 
709963(AGMO)
MMU: 
319660(Agmo)
RNO: 
362732(Agmo)
CFA: 
475247(AGMO)
AML: 
FCA: 
101082991(AGMO)
BTA: 
613658(AGMO)
SSC: 
100513371(AGMO)
ECB: 
100052771(AGMO)
MDO: 
100022353(AGMO)
SHR: 
100934114(AGMO)
OAA: 
100080816
GGA: 
772374(AGMO)
TGU: 
100223605(AGMO)
ACS: 
100564327
XTR: 
496770(agmo)
DRE: 
405819(agmo)
TRU: 
101062615
OLA: 
101160098
BFO: 
BRAFLDRAFT_214818
CIN: 
100176978
SPU: 
579307
AME: 
413590
NVI: 
100119956(NV15564)
TCA: 
657448
API: 
100159128
CEL: 
CELE_BE10.2(agmo-1)
CBR: 
CBG15741
NVE: 
NEMVE_v1g124731
TAD: 
TRIADDRAFT_53564
AQU: 
100640784
DDI: 
DDB_G0277137
DPP: 
DICPUDRAFT_51289
 » show all
Taxonomy
Reference
1  [PMID:6840084]
  Authors
Ishibashi T, Imai Y.
  Title
Solubilization and partial characterization of alkylglycerol monooxygenase from rat liver microsomes.
  Journal
Eur. J. Biochem. 132 (1983) 23-7.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:4383918]
  Authors
Pfleger RC, Piantadosi C, Snyder F.
  Title
The biocleavage of isomeric glyceryl ethers by soluble liver enzymes in a variety of species.
  Journal
Biochim. Biophys. Acta. 144 (1967) 633-48.
  Organism
Mus musculus [GN:mmu], Canis familiaris [GN:cfa], Cavia porcellus, Meriones unguiculatus, Mesocricetus auratus, Oryctolagus cuniculus, Limax maximus
Reference
3  [PMID:4355017]
  Authors
Snyder F, Malone B, Piantadosi C.
  Title
Tetrahydropteridine-dependent cleavage enzyme for O-alkyl lipids: substrate specificity.
  Journal
Biochim. Biophys. Acta. 316 (1973) 259-65.
  Organism
Rattus norvegicus [GN:rno]
Reference
4  [PMID:4402391]
  Authors
Soodsma JF, Piantadosi C, Snyder F.
  Title
Partial characterization of the alkylglycerol cleavage enzyme system of rat liver.
  Journal
J. Biol. Chem. 247 (1972) 3923-9.
  Organism
Rattus norvegicus [GN:rno]
Reference
5  [PMID:14247652]
  Authors
TIETZ A, LINDBERG M, KENNEDY EP.
  Title
A NEW PTERIDINE-REQUIRING ENZYME SYSTEM FOR THE OXIDATION OF GLYCERYL ETHERS.
  Journal
J. Biol. Chem. 239 (1964) 4081-90.
  Organism
Rattus norvegicus [GN:rno]
Reference
6  [PMID:9436181]
  Authors
Taguchi H, Armarego WL
  Title
Glyceryl-ether monooxygenase [EC 1.14.16.5]. A microsomal enzyme of ether lipid metabolism.
  Journal
Med. Res. Rev. 18 (1998) 43-89.
Reference
7  [PMID:19007315]
  Authors
Watschinger K, Keller MA, Hermetter A, Golderer G, Werner-Felmayer G, Werner ER
  Title
Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal  ion and tetrahydrobiopterin dependence.
  Journal
Biol. Chem. 390 (2009) 3-10.
Reference
8  [PMID:17303893]
  Authors
Werner ER, Hermetter A, Prast H, Golderer G, Werner-Felmayer G
  Title
Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay.
  Journal
J. Lipid. Res. 48 (2007) 1422-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-82-9
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