KEGG   ENZYME: 1.14.16.5Help
Entry
EC 1.14.16.5                Enzyme                                 

Name
alkylglycerol monooxygenase;
glyceryl-ether monooxygenase;
glyceryl-ether cleaving enzyme;
glyceryl ether oxygenase;
glyceryl etherase;
O-alkylglycerol monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase
Reaction(IUBMB)
1-O-alkyl-sn-glycerol + tetrahydrobiopterin + O2 = 1-O-(1-hydroxyalkyl)-sn-glycerol + dihydrobiopterin + H2O [RN:R04044]
Reaction(KEGG)
Substrate
1-O-alkyl-sn-glycerol [CPD:C02773];
tetrahydrobiopterin [CPD:C00272];
O2 [CPD:C00007]
Product
1-O-(1-hydroxyalkyl)-sn-glycerol;
dihydrobiopterin [CPD:C00268];
H2O [CPD:C00001]
Comment
The enzyme cleaves alkylglycerols, but does not cleave alkenylglycerols (plasmalogens). Requires non-heme iron [7], reduced glutathione and phospholipids for full activity. The product spontaneously breaks down to form a fatty aldehyde and glycerol.
History
EC 1.14.16.5 created 1972 as EC 1.14.99.17, transferred 1976 to EC 1.14.16.5, modified 2010
Orthology
K15537  alkylglycerol monooxygenase
Genes
HSA: 392636(AGMO)
PTR: 463272(AGMO)
PPS: 100988512(AGMO)
GGO: 101133058(AGMO) 109027599
PON: 100438998(AGMO)
NLE: 100598360(AGMO)
MCC: 709963(AGMO)
MCF: 102140354(AGMO)
CSAB: 103226453(AGMO)
RRO: 104668141(AGMO)
RBB: 108540080(AGMO)
CJC: 100393907(AGMO)
SBQ: 101046685(AGMO)
MMU: 319660(Agmo)
RNO: 362732(Agmo)
CGE: 100752746(Agmo)
NGI: 103726803(Agmo)
HGL: 106008946(Agmo)
CCAN: 109676238(Agmo)
OCU: 100339522(AGMO)
TUP: 102487435(AGMO)
CFA: 475247(AGMO)
AML: 100473316
UMR: 103658833(AGMO)
ORO: 101371286(AGMO)
FCA: 101082991(AGMO)
PTG: 102953129(AGMO)
AJU: 106971349(AGMO)
BTA: 613658(AGMO)
BOM: 102287910(AGMO)
BIU: 109557267(AGMO)
PHD: 102316332(AGMO)
CHX: 102177125(AGMO)
OAS: 101103313(AGMO)
SSC: 100513371(AGMO)
CFR: 102508044(AGMO)
CDK: 105092904(AGMO)
BACU: 103007090(AGMO)
LVE: 103084449(AGMO)
OOR: 101269844(AGMO)
ECB: 100052771(AGMO)
EPZ: 103557381(AGMO) 103557963
EAI: 106837998(AGMO)
MYB: 102253210(AGMO)
MYD: 102767015(AGMO)
HAI: 109391917(AGMO)
RSS: 109445107(AGMO)
PALE: 102888896(AGMO)
LAV: 100659232(AGMO)
MDO: 100022353(AGMO)
SHR: 100934114(AGMO)
OAA: 100080816(AGMO)
GGA: 772374(AGMO)
MGP: 100545428(AGMO)
CJO: 107309232(AGMO)
APLA: 101801837(AGMO)
ACYG: 106037493(AGMO)
TGU: 100223605(AGMO)
GFR: 102041091(AGMO)
FAB: 101808659(AGMO)
PHI: 102106287(AGMO)
PMAJ: 107200909(AGMO)
CCW: 104689135(AGMO)
FPG: 101915982(AGMO)
FCH: 102045933(AGMO)
CLV: 102091863(AGMO)
EGZ: 104134572(AGMO)
AAM: 106483529(AGMO)
ASN: 102371452 102377527(AGMO)
AMJ: 102576260(AGMO)
PSS: 102463873(AGMO)
CMY: 102934438(AGMO)
CPIC: 101939766(AGMO)
ACS: 100564327(agmo)
PVT: 110072843(AGMO)
PBI: 103059739(AGMO)
XLA: 108718854(agmo.L)
XTR: 496770(agmo)
NPR: 108788016(AGMO)
DRE: 405819(agmo)
SRX: 107752262(agmo)
SANH: 107704769
SGH: 107582294 107587066(agmo)
IPU: 108278345(agmo)
AMEX: 103030268(agmo)
TRU: 101062615(agmo)
LCO: 104937453(agmo)
NCC: 104960391(agmo)
MZE: 101470736(agmo)
OLA: 101160098(agmo)
XMA: 102222346(agmo)
PRET: 103477678(agmo)
NFU: 107379193(agmo)
CSEM: 103388988(agmo)
LCF: 108883212(agmo)
HCQ: 109521066(agmo)
BPEC: 110159168(agmo)
SASA: 106582276 106605209(agmo)
ELS: 105021899(agmo)
SFM: 108927432(agmo)
LCM: 102351412(AGMO)
CMK: 103182639(agmo)
CIN: 100176978
APLC: 110974514
AME: 413590(GB18268)
BIM: 100744163
BTER: 100651518
SOC: 105197322
AEC: 105154653
ACEP: 105622458
PBAR: 105432235
HST: 105190251
CFO: 105248680
LHU: 105672268
NVI: 100119956
TCA: 657448
DPA: 109538878
NVL: 108558948
PMAC: 106716198
PXY: 105398573
API: 100159128
DNX: 107173082
CEL: CELE_BE10.2(agmo-1)
CBR: CBG15741
MYI: 110442646
OBI: 106872128
EPA: 110239716
AQU: 100640784
APRO: F751_6684
DFA: DFA_08160
SMIN: v1.2.017513.t1(symbB.v1.2.017513.t1)
NGR: NAEGRDRAFT_81535(AM51)
 » show all
Taxonomy
Reference
1  [PMID:6840084]
  Authors
Ishibashi T, Imai Y.
  Title
Solubilization and partial characterization of alkylglycerol monooxygenase from rat liver microsomes.
  Journal
Eur. J. Biochem. 132 (1983) 23-7.
Reference
2  [PMID:4383918]
  Authors
Pfleger RC, Piantadosi C, Snyder F.
  Title
The biocleavage of isomeric glyceryl ethers by soluble liver enzymes in a variety of species.
  Journal
Biochim. Biophys. Acta. 144 (1967) 633-48.
Reference
3  [PMID:4355017]
  Authors
Snyder F, Malone B, Piantadosi C.
  Title
Tetrahydropteridine-dependent cleavage enzyme for O-alkyl lipids: substrate specificity.
  Journal
Biochim. Biophys. Acta. 316 (1973) 259-65.
Reference
4  [PMID:4402391]
  Authors
Soodsma JF, Piantadosi C, Snyder F.
  Title
Partial characterization of the alkylglycerol cleavage enzyme system of rat liver.
  Journal
J. Biol. Chem. 247 (1972) 3923-9.
Reference
5  [PMID:14247652]
  Authors
TIETZ A, LINDBERG M, KENNEDY EP.
  Title
A NEW PTERIDINE-REQUIRING ENZYME SYSTEM FOR THE OXIDATION OF GLYCERYL ETHERS.
  Journal
J. Biol. Chem. 239 (1964) 4081-90.
Reference
6  [PMID:9436181]
  Authors
Taguchi H, Armarego WL
  Title
Glyceryl-ether monooxygenase [EC 1.14.16.5]. A microsomal enzyme of ether lipid metabolism.
  Journal
Med. Res. Rev. 18 (1998) 43-89.
Reference
7  [PMID:19007315]
  Authors
Watschinger K, Keller MA, Hermetter A, Golderer G, Werner-Felmayer G, Werner ER
  Title
Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal  ion and tetrahydrobiopterin dependence.
  Journal
Biol. Chem. 390 (2009) 3-10.
Reference
8  [PMID:17303893]
  Authors
Werner ER, Hermetter A, Prast H, Golderer G, Werner-Felmayer G
  Title
Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay.
  Journal
J. Lipid. Res. 48 (2007) 1422-7.
Other DBs
ExplorEnz - The Enzyme Database: 1.14.16.5
IUBMB Enzyme Nomenclature: 1.14.16.5
ExPASy - ENZYME nomenclature database: 1.14.16.5
BRENDA, the Enzyme Database: 1.14.16.5
CAS: 37256-82-9

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