KEGG   ENZYME: 1.14.16.6Help
Entry
EC 1.14.16.6                Enzyme                                 

Name
mandelate 4-monooxygenase;
L-mandelate 4-hydroxylase;
mandelic acid 4-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
(S)-2-hydroxy-2-phenylacetate + tetrahydrobiopterin + O2 = (S)-4-hydroxymandelate + dihydrobiopterin + H2O [RN:R03794]
Reaction(KEGG)
Substrate
(S)-2-hydroxy-2-phenylacetate [CPD:C01984];
tetrahydrobiopterin [CPD:C00272];
O2 [CPD:C00007]
Product
(S)-4-hydroxymandelate [CPD:C03198];
dihydrobiopterin [CPD:C00268];
H2O [CPD:C00001]
Comment
Requires Fe2+.
History
EC 1.14.16.6 created 1984
Pathway
Aminobenzoate degradation
Microbial metabolism in diverse environments
Reference
1  [PMID:9909]
  Authors
Bhat SG, Vaidyanathan CS.
  Title
Purifications and properties of L-mandelate- 4-hydroxylase from Pseudomonas convexa.
  Journal
Arch. Biochem. Biophys. 176 (1976) 314-23.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
39459-82-0

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