KEGG   ENZYME: 1.14.16.7Help
Entry
EC 1.14.16.7                Enzyme                                 

Name
phenylalanine 3-monooxygenase;
PacX;
phenylalanine 3-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
L-phenylalanine + tetrahydrobiopterin + O2 = 3-hydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin [RN:R10729]
Reaction(KEGG)
Substrate
L-phenylalanine [CPD:C00079];
tetrahydrobiopterin [CPD:C00272];
O2 [CPD:C00007]
Product
3-hydroxy-L-phenylalanine [CPD:C20807];
4a-hydroxytetrahydrobiopterin [CPD:C15522]
Comment
The enzyme from the bacterium Streptomyces coeruleorubidus forms 3-hydroxy-L-phenylalanine (i.e. m-L-tyrosine), which is one of the building blocks in the biosynthesis of the uridyl peptide antibiotics pacidamycins.
History
EC 1.14.16.7 created 2014
Reference
1  [PMID:21615132]
  Authors
Zhang W, Ames BD, Walsh CT
  Title
Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis.
  Journal
Biochemistry. 50 (2011) 5401-3.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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