KEGG   ENZYME: 1.14.18.3Help
Entry
EC 1.14.18.3                Enzyme                                 

Name
methane monooxygenase (particulate)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With another compound as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
methane,quinol:oxygen oxidoreductase
Reaction(IUBMB)
methane + quinol + O2 = methanol + quinone + H2O [RN:R09518]
Reaction(KEGG)
Substrate
methane [CPD:C01438];
quinol [CPD:C15603];
O2 [CPD:C00007]
Product
methanol [CPD:C00132];
quinone [CPD:C15602];
H2O [CPD:C00001]
Comment
Contains copper. It is membrane-bound, in contrast to the soluble methane monooxygenase (EC 1.14.13.25).
History
EC 1.14.18.3 created 2011
Pathway
Methane metabolism
Metabolic pathways
Orthology
K10944  
methane/ammonia monooxygenase subunit A
Genes
MCA: 
MCA1797(pmoA) MCA2854(pmoA2)
MMT: 
MDN: 
MAH: 
NOC: 
NHL: 
NWA: 
NEU: 
NE0944(amoA1) NE2063(amoA2)
NET: 
NIT: 
NII: 
NCO: 
NUR: 
NMU: 
MSC: 
BN69_0203(pmoA2) BN69_2827(pmoA) BN69_3534(pmoA)
MRH: 
MCB: 
MIN: 
Minf_1507(pmoA) Minf_1510(pmoA) Minf_1590(pmoA)
NIO: 
MOX: 
DAMO_2450(pmoA)
NMR: 
NIR: 
NID: 
NIN: 
NKR: 
CSY: 
NGA: 
NVN: 
NEV: 
TAA: 
NBV: 
TAH: 
 » show all
Taxonomy
Reference
1  [PMID:7646068]
  Authors
Shiemke AK, Cook SA, Miley T, Singleton P
  Title
Detergent solubilization of membrane-bound methane monooxygenase requires plastoquinol analogs as electron donors.
  Journal
Arch. Biochem. Biophys. 321 (1995) 421-8.
  Sequence
Reference
2  [PMID:12379148]
  Authors
Basu P, Katterle B, Andersson KK, Dalton H
  Title
The membrane-associated form of methane mono-oxygenase from Methylococcus capsulatus (Bath) is a copper/iron protein.
  Journal
Biochem. J. 369 (2003) 417-27.
  Sequence
Reference
3  [PMID:16101279]
  Authors
Kitmitto A, Myronova N, Basu P, Dalton H
  Title
Characterization and structural analysis of an active particulate methane monooxygenase trimer from Methylococcus capsulatus (Bath).
  Journal
Biochemistry. 44 (2005) 10954-65.
  Sequence
Reference
4  [PMID:17444606]
  Authors
Balasubramanian R, Rosenzweig AC
  Title
Structural and mechanistic insights into methane oxidation by particulate methane monooxygenase.
  Journal
Acc. Chem. Res. 40 (2007) 573-80.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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