KEGG   ENZYME: 1.14.18.5Help
Entry
EC 1.14.18.5                Enzyme                                 

Name
sphingolipid C4-monooxygenase;
sphinganine C4-monooxygenase;
sphingolipid C4-hydroxylase;
SUR2 (gene name);
SBH1 (gene name);
SBH2 (gene name);
DEGS2 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With another compound as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
Reaction(IUBMB)
a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4R)-4-hydroxysphinganine ceramide + 2 ferricytochrome b5 + H2O [RN:R06526]
Reaction(KEGG)
R06526;
(other) R06525
Show
Substrate
dihydroceramide [CPD:C12126];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
(4R)-4-hydroxysphinganine ceramide [CPD:C12145];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001]
Comment
The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes. Some enzymes are bifunctional and also catalyse EC 1.14.19.17, sphingolipid 4-desaturase [4].
History
EC 1.14.18.5 created 2012 as EC 1.14.13.169, transferred 2015 to EC 1.14.18.5
Pathway
Sphingolipid metabolism
Metabolic pathways
Orthology
K04713  
sphinganine C4-monooxygenase
Genes
ATH: 
AT1G14290(SBH2) AT1G69640(SBH1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0002s06230g(POPTRDRAFT_816189) POPTR_0005s22160g(POPTRDRAFT_559449) POPTR_0005s22170g(POPTRDRAFT_831564)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
4330718(OJ1118_G04.23) 4340921(OJ1230_H04.27) 4343979 9268279
DOSA: 
Os02t0745700-01(Os02g0745700) Os06t0226950-01(Os06g0226950) Os06t0330400-00(Os06g0330400) Os07t0627700-01(Os07g0627700)
OBR: 
BDI: 
SBI: 
SORBI_02g040020(SORBIDRAFT_02g040020) SORBI_03g030030(SORBIDRAFT_03g030030) SORBI_03g033740(SORBIDRAFT_03g033740) SORBI_04g000890(SORBIDRAFT_04g000890) SORBI_04g000900(SORBIDRAFT_04g000900) SORBI_04g000930(SORBIDRAFT_04g000930) SORBI_04g000940(SORBIDRAFT_04g000940) SORBI_04g027990(SORBIDRAFT_04g027990) SORBI_04g029320(SORBIDRAFT_04g029320) SORBI_05g021500(SORBIDRAFT_05g021500) SORBI_10g008040(SORBIDRAFT_10g008040)
ZMA: 
100273604(GRMZM2G163008) 100273655(GRMZM2G044175) 100282881(GRMZM2G124276) 100283399 103636134(GRMZM2G030118) 103651403 103652928 103655903 107436073
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
SCE: 
YDR297W(SUR2)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A01360(NCAS0A01360)
NDI: 
NDAI_0C02160(NDAI0C02160)
TPF: 
TPHA_0E01350(TPHA0E01350)
TBL: 
TBLA_0A02900(TBLA0A02900)
TDL: 
TDEL_0E03130(TDEL0E03130)
KAF: 
KAFR_0D04510(KAFR0D04510)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT41476(NEUTE1DRAFT_41476)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1746174(AO090005000995)
ANG: 
ANI_1_1368014(An01g10030)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT118992(AGABI1DRAFT_118992)
ABV: 
AGABI2DRAFT206283(AGABI2DRAFT_206283)
CPUT: 
SLA: 
WSE: 
WIC: 
PFP: 
MGL: 
PGR: 
MLR: 
ACAN: 
 » show all
Taxonomy
Reference
1  [PMID:9368039]
  Authors
Haak D, Gable K, Beeler T, Dunn T
  Title
Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p.
  Journal
J. Biol. Chem. 272 (1997) 29704-10.
  Sequence
[sce:YDR297W]
Reference
2  [PMID:9556590]
  Authors
Grilley MM, Stock SD, Dickson RC, Lester RL, Takemoto JY
  Title
Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae.
  Journal
J. Biol. Chem. 273 (1998) 11062-8.
  Sequence
[sce:YDR297W]
Reference
3  [PMID:11297741]
  Authors
Sperling P, Ternes P, Moll H, Franke S, Zahringer U, Heinz E
  Title
Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana.
  Journal
FEBS. Lett. 494 (2001) 90-4.
  Sequence
Reference
4  [PMID:11937514]
  Authors
Ternes P, Franke S, Zahringer U, Sperling P, Heinz E
  Title
Identification and characterization of a sphingolipid delta 4-desaturase family.
  Journal
J. Biol. Chem. 277 (2002) 25512-8.
  Sequence
[mmu:70059]
Reference
5  [PMID:15063729]
  Authors
Mizutani Y, Kihara A, Igarashi Y
  Title
Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation.
  Journal
FEBS. Lett. 563 (2004) 93-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system