KEGG   ENZYME: 1.14.18.7Help
Entry
EC 1.14.18.7                Enzyme                                 

Name
dihydroceramide fatty acyl 2-hydroxylase;
FAH1 (gene name);
FAH2 (gene name);
plant sphingolipid fatty acid 2-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With another compound as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
dihydroceramide,ferrocytochrome-b5:oxygen oxidoreductase (fatty acyl 2-hydroxylating)
Reaction(IUBMB)
a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (2'R)-2'-hydroxydihydroceramide + 2 ferricytochrome b5 + H2O [RN:R11003]
Reaction(KEGG)
Substrate
dihydroceramide [CPD:C12126];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
(2'R)-2'-hydroxydihydroceramide [CPD:C21021];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001]
Comment
The enzyme, characterized from plants, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to sphinganine during de novo ceramide synthesis. The enzyme requires an external cytochrome b5 as the electron donor. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.6, 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase.
History
EC 1.14.18.7 created 2015
Orthology
K19706  
dihydroceramide fatty acyl 2-hydroxylase
Genes
ATH: 
AT2G34770(FAH1) AT4G20870(FAH2)
ALY: 
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NNU: 
OSA: 
DOSA: 
Os03t0780800-01(Os03g0780800) Os12t0628400-01(Os12g0628400)
OBR: 
BDI: 
SBI: 
SORBI_01g006300(SORBIDRAFT_01g006300) SORBI_08g022360(SORBIDRAFT_08g022360)
ZMA: 
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 » show all
Taxonomy
Reference
1  [PMID:19054355]
  Authors
Nagano M, Ihara-Ohori Y, Imai H, Inada N, Fujimoto M, Tsutsumi N, Uchimiya H, Kawai-Yamada M
  Title
Functional association of cell death suppressor, Arabidopsis Bax inhibitor-1, with fatty acid 2-hydroxylation through cytochrome b(5).
  Journal
Plant. J. 58 (2009) 122-34.
  Sequence
Reference
2  [PMID:22635113]
  Authors
Nagano M, Takahara K, Fujimoto M, Tsutsumi N, Uchimiya H, Kawai-Yamada M
  Title
Arabidopsis sphingolipid fatty acid 2-hydroxylases (AtFAH1 and AtFAH2) are functionally differentiated in fatty acid 2-hydroxylation and stress responses.
  Journal
Plant. Physiol. 159 (2012) 1138-48.
  Sequence
Reference
3  [PMID:22918503]
  Authors
Nagano M, Uchimiya H, Kawai-Yamada M
  Title
Plant sphingolipid fatty acid 2-hydroxylases have unique characters unlike their  animal and fungus counterparts.
  Journal
Plant. Signal. Behav. 7 (2012) 1388-92.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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