Delta12-fatty-acid desaturase;
Delta12 fatty acid desaturase;
Delta12(omega6)-desaturase;
oleoyl-CoA Delta12 desaturase;
Delta12 desaturase;
Delta12-desaturase

Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

acyl-CoA,hydrogen donor:oxygen Delta12-oxidoreductase

acyl-CoA + reduced acceptor + O2 = Delta12-acyl-CoA + acceptor + 2 H2O

acyl-CoA [CPD:C00040];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]

In the yeast Lipomyces starkeyi [3] and in the American cockroach [1], this microsomal enzyme converts oleoyl-CoA into linoleoyl-CoA. In the moths Cadra cautella and Spodoptera, the enzyme converts (Z)-tetradec-9-enoic acid into (9Z,12E)-tetradeca-9,12-dienoic acid, which is reduced and acetylated to form the acetate ester pheromone [2].

1  [PMID:2248971]

Borgeson CE, de Renobales M, Blomquist GJ.

Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate.

Biochim. Biophys. Acta. 1047 (1990) 135-40.

Periplaneta americana

2  [PMID:9230926]

Jurenka RA.

Biosynthetic pathway for producing the sex pheromone component (Z,E)-9,12-tetradecadienyl acetate in moths involves a delta 12 desaturase.

Cell. Mol. Life. Sci. 53 (1997) 501-5.

Cadra cautella

3  [PMID:8900454]

Lomascolo A, Dubreucq E, Galzy P.

Study of the delta 12-desaturase system of Lipomyces starkeyi.

Lipids. 31 (1996) 253-9.

Lipomyces starkeyi

4  [PMID:9829122]

Tocher DR, Leaver MJ, Hodgson PA.

Recent advances in the biochemistry and molecular biology of fatty acyl desaturases.

Prog. Lipid. Res. 37 (1998) 73-117.

Synechocystis sp. [GN:syn], Synechococcus sp. [GN:syp]