KEGG   ENZYME: 1.14.20.2Help
Entry
EC 1.14.20.2                Enzyme                                 

Name
2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase;
BX6 (gene name);
DIBOA-Glc dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and the other dehydrogenated
BRITE hierarchy
Sysname
(2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside:oxygen oxidoreductase (7-hydroxylating)
Reaction(IUBMB)
(2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside + 2-oxoglutarate + O2 = (2R)-4,7-dihydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside + succinate + CO2 + H2O [RN:R08972]
Reaction(KEGG)
Substrate
(2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(2R)-4,7-dihydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside;
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses).
History
EC 1.14.20.2 created 2012
Pathway
Benzoxazinoid biosynthesis
Orthology
K13229  
2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase
Genes
ZMA: 
541977(bx6)
Taxonomy
Reference
1  [PMID:18192444]
  Authors
Jonczyk R, Schmidt H, Osterrieder A, Fiesselmann A, Schullehner K, Haslbeck M, Sicker D, Hofmann D, Yalpani N, Simmons C, Frey M, Gierl A.
  Title
Elucidation of the final reactions of DIMBOA-glucoside biosynthesis in maize: characterization of Bx6 and Bx7.
  Journal
Plant. Physiol. 146 (2008) 1053-63.
  Sequence
[zma:541977]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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