KEGG   ENZYME: 1.14.21.4Help
Entry
EC 1.14.21.4                Enzyme                                 

Name
salutaridine synthase;
(R)-reticuline oxidase (C-C phenol-coupling)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and the other dehydrogenated
BRITE hierarchy
Sysname
(R)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling)
Reaction(IUBMB)
(R)-reticuline + NADPH + H+ + O2 = salutaridine + NADP+ + 2 H2O [RN:R04696]
Reaction(KEGG)
Substrate
(R)-reticuline [CPD:C05178];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
salutaridine [CPD:C05179];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate enzyme (P-450). Forms the morphinan alkaloid salutaridine by intramolecular phenol oxidation of reticuline without the incorporation of oxygen into the product.
History
EC 1.14.21.4 created 1999 as EC 1.1.3.35, transferred 2002 to EC 1.14.21.4
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13391  
salutaridine synthase
Reference
1
  Authors
Gerady, R. and Zenk, M.H.
  Title
Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum.
  Journal
Phytochemistry 32 (1993) 79-86.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
149433-84-1

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