| Entry |
|
|---|
| Name |
salutaridine synthase;
(R)-reticuline oxidase (C-C phenol-coupling) |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and the other dehydrogenated
 |
|---|
| Sysname |
(R)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling) |
|---|
| Reaction(IUBMB) |
(R)-reticuline + NADPH + H+ + O2 = salutaridine + NADP+ + 2 H2O
[RN:R04696] |
|---|
| Reaction(KEGG) |
R04696
 |
|---|
| Substrate |
(R)-reticuline [CPD:C05178];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
salutaridine [CPD:C05179];
NADP+ [CPD:C00006];
H2O [CPD:C00001] |
|---|
| Comment |
A heme-thiolate enzyme (P-450). Forms the morphinan alkaloid
salutaridine by intramolecular phenol oxidation of reticuline
without the incorporation of oxygen into the product. |
|---|
| Pathway |
ec00950 Isoquinoline alkaloid biosynthesis
ec01100 Metabolic pathways
ec01110 Biosynthesis of secondary metabolites |
|---|
| Orthology |
K13391 cytochrome P450, family 719, subfamily B, polypeptide 1
(salutaridine synthase) |
|---|
Reference
Authors
Title
Journal
|
1
Gerady, R. and Zenk, M.H.
Formation of salutaridine from (R)-reticuline by a membrane-bound
cytochrome P-450 enzyme from Papaver somniferum.
Phytochemistry 32 (1993) 79-86. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.21.4
IUBMB Enzyme Nomenclature: 1.14.21.4
ExPASy - ENZYME nomenclature database: 1.14.21.4
BRENDA, the Enzyme Database: 1.14.21.4
CAS: 149433-84-1 |
|---|
