KEGG   ENZYME: 1.14.99.11Help
Entry
EC 1.14.99.11               Enzyme                                 
Name
estradiol 6beta-monooxygenase;
estradiol 6beta-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
Miscellaneous
BRITE hierarchy
Sysname
estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)
Reaction(IUBMB)
estradiol-17beta + AH2 + O2 = 6beta-hydroxyestradiol-17beta + A + H2O [RN:R03086]
Reaction(KEGG)
Substrate
estradiol-17beta [CPD:C00951];
AH2 [CPD:C00030];
O2 [CPD:C00007]
Product
6beta-hydroxyestradiol-17beta [CPD:C03935];
A [CPD:C00028];
H2O [CPD:C00001]
Pathway
Steroid hormone biosynthesis
Reference
1
  Authors
Haines, W.J.
  Title
The biosynthesis of adrenal cortex hormones.
  Journal
Recent Progr. Hormone Res. 7 (1952) 255-305.
Reference
2
  Authors
Mueller, G.C. and Rumney, G.
  Title
Formation of 6beta-hydroxy and 6-keto derivatives of estradiol-16-C14 by mouse liver microsomes.
  Journal
J. Am. Chem. Soc. 79 (1957) 1004-1005.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-70-3
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