| Entry |
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| Name |
androst-4-ene-3,17-dione monooxygenase;
androstene-3,17-dione hydroxylase;
androst-4-ene-3,17-dione 17-oxidoreductase;
androst-4-ene-3,17-dione hydroxylase;
androstenedione monooxygenase;
4-androstene-3,17-dione monooxygenase
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| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
Miscellaneous
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| Sysname |
androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)
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| Reaction(IUBMB) |
androstenedione + AH2 + O2 = testololactone + A + H2O [RN: R01833]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Has a wide specificity. A single enzyme from the ascomycete Neonectria radicicola (EC 1.14.13.54, ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.14.99.4, progesterone monooxygenase.
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| Pathway |
| Steroid hormone biosynthesis |
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| Reference |
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| Authors |
PRAIRIE RL, TALALAY P. |
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| Title |
Enzymatic formation of testololactone. |
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| Journal |
Biochemistry. 2 (1963) 203-8. |
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| Organism |
Penicillium lilacinum |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37256-74-9 |
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