KEGG   ENZYME: 1.14.99.14Help
Entry
EC 1.14.99.14               Enzyme                                 

Name
progesterone 11alpha-monooxygenase;
progesterone 11alpha-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)
Reaction(IUBMB)
progesterone + AH2 + O2 = 11alpha-hydroxyprogesterone + A + H2O [RN:R02214]
Reaction(KEGG)
Substrate
progesterone [CPD:C00410];
AH2 [CPD:C00030];
O2 [CPD:C00007]
Product
11alpha-hydroxyprogesterone [CPD:C03747];
A [CPD:C00028];
H2O [CPD:C00001]
History
EC 1.14.99.14 created 1972
Pathway
Steroid hormone biosynthesis
Reference
1  [PMID:5417182]
  Authors
Shibahara M, Moody JA, Smith LL.
  Title
Microbial hydroxylations. V. 11-alpha-hydroxylation of progesterone by cell-free preparations of Aspergillus ochraceus.
  Journal
Biochim. Biophys. Acta. 202 (1970) 172-9.
  Organism
Aspergillus ochraceus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-77-2

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