KEGG   ENZYME: 1.14.99.19Help
Entry
EC 1.14.99.19               Enzyme                                 

Name
plasmanylethanolamine desaturase;
alkylacylglycerophosphoethanolamine desaturase;
alkylacylglycero-phosphorylethanolamine dehydrogenase;
dehydrogenase, alkyl-acylglycerophosphorylethanolamine;
1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase;
1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxygen oxidoreductase
Reaction(IUBMB)
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O [RN:R04571]
Reaction(KEGG)
Substrate
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine [CPD:C04475];
AH2 [CPD:C00030];
O2 [CPD:C00007]
Product
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine [CPD:C04756];
A [CPD:C00028];
H2O [CPD:C00001]
Comment
Requires NADPH or NADH. May involve cytochrome b5. Requires Mg2+ and ATP.
History
EC 1.14.99.19 created 1976
Pathway
Ether lipid metabolism
Metabolic pathways
Reference
1  [PMID:4144394]
  Authors
Paltauf F, Holasek A.
  Title
Enzymatic synthesis of plasmalogens. Characterization of the 1-O-alkyl-2-acyl-8n-glycero-3-phosphorylethanolamine desaturase from mucosa of hamster small intestine.
  Journal
J. Biol. Chem. 248 (1973) 1609-15.
Reference
2  [PMID:4403444]
  Authors
Wykle RL, Blank ML, Malone B, Snyder F.
  Title
Evidence for a mixed function oxidase in the biosynthesis of ethanolamine plasmalogens from 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine.
  Journal
J. Biol. Chem. 247 (1972) 5442-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
39391-13-4

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