KEGG   ENZYME: 1.14.99.2Help
Entry
EC 1.14.99.2                Enzyme                                 

Name
kynurenine 7,8-hydroxylase;
kynurenic acid hydroxylase;
kynurenic hydroxylase;
kynurenate 7,8-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
Reaction(IUBMB)
kynurenate + AH2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + A [RN:R03441]
Reaction(KEGG)
Substrate
kynurenate [CPD:C01717];
AH2 [CPD:C00030];
O2 [CPD:C00007]
Product
7,8-dihydro-7,8-dihydroxykynurenate [CPD:C01249];
A [CPD:C00028]
History
EC 1.14.99.2 created 1965 as EC 1.14.1.4, transferred 1972 to EC 1.14.99.2
Pathway
Tryptophan metabolism
Reference
1  [PMID:13984873]
  Authors
TANIUCHI H, HAYAISHI O.
  Title
Studies on the metabolism of kynurenic acid. III. Enzymatic formation of 7,8-dihydroxykynurenic acid from kynurenic acid.
  Journal
J. Biol. Chem. 238 (1963) 283-93.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-63-4

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