KEGG   ENZYME: 1.14.99.26Help
Entry
EC 1.14.99.26               Enzyme                                 

Name
2-hydroxypyridine 5-monooxygenase;
2-hydroxypyridine oxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
2-hydroxypyridine + AH2 + O2 = 2,5-dihydroxypyridine + A + H2O [RN:R03206]
Reaction(KEGG)
Substrate
2-hydroxypyridine [CPD:C02502];
AH2 [CPD:C00030];
O2 [CPD:C00007]
Product
2,5-dihydroxypyridine [CPD:C01059];
A [CPD:C00028];
H2O [CPD:C00001]
Comment
Also oxidizes 2,5-dihydroxypyridine, but does not act on 3-hydroxypyridine, 4-hydroxypyridine or 2,6-dihydroxypyridine.
History
EC 1.14.99.26 created 1989
Reference
1
  Authors
Sharma, M.L., Kaul, S.M. and Shukla, O.P.
  Title
Metabolism of 2-hydroxypyridine by Bacillus brevis (INA).
  Journal
Biol. Membr. 9 (1984) 43-52.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
96779-45-2

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