KEGG   ENZYME: 1.14.99.27Help
Entry
EC 1.14.99.27               Enzyme                                 

Name
juglone 3-monooxygenase;
juglone hydroxylase;
naphthoquinone hydroxylase;
naphthoquinone-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
5-hydroxy-1,4-naphthoquinone + AH2 + O2 = 3,5-dihydroxy-1,4-naphthoquinone + A + H2O [RN:R04327]
Reaction(KEGG)
Substrate
5-hydroxy-1,4-naphthoquinone [CPD:C03840];
AH2 [CPD:C00030];
O2 [CPD:C00007]
Product
3,5-dihydroxy-1,4-naphthoquinone [CPD:C04110];
A [CPD:C00028];
H2O [CPD:C00001]
Comment
Also acts on 1,4-naphthoquinone, naphthazarin and 2-chloro-1,4-naphthoquinone, but not on other related compounds.
History
EC 1.14.99.27 created 1989
Reference
1  [PMID:4041238]
  Authors
Rettenmaier H, Lingens F.
  Title
Purification and some properties of two isofunctional juglone hydroxylases from Pseudomonas putida J1.
  Journal
Biol. Chem. Hoppe. Seyler. 366 (1985) 637-46.
  Organism
Pseudomonas putida
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
98865-54-4

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