| Entry |
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| Name |
deoxyhypusine monooxygenase;
deoxyhypusine hydroxylase;
deoxyhypusine dioxygenase
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| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
Miscellaneous
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| Sysname |
deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)
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| Reaction(IUBMB) |
protein N6-(4-aminobutyl)-L-lysine + AH2 + O2 = protein N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine + A + H2O [RN: R04437]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
protein N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine [CPD: C04679];
A [CPD: C00028];
H2O [CPD: C00001]
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| Comment |
The enzyme catalyses the final step in the formation of the amino acid hypusine in the eukaryotic initiation factor 5A.
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| Orthology |
| deoxyhypusine monooxygenase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | API: | | PHU: | | CEL: | | BMY: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | ATH: | | ALY: | | GMX: | | CSV: | | RCU: | | POP: | | VVI: | | DOSA: | | BDI: | | SBI: | | ZMA: | | SMO: | | PPP: | | CRE: | | VCN: | | OLU: | | OTA: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | SPO: | | CNE: | | CNB: | | CGI: | | LBC: | | MPR: | | CCI: | | SCM: | | UMA: | | MGL: | | PGR: | | ECU: | | EIN: | | EHE: | | NCE: | | MBR: | | NGR: | | DPP: | | PCB: | | PBE: | | PKN: | | PVX: | | PCY: | | BBO: | | TGO: | | PTM: | | LIF: | | LDO: | | LMI: | | LBZ: | | TPS: | | PIF: | | NKR: | | CSY: | | NGA: | |
» show all
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| Reference |
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| Authors |
Abbruzzese A, Park MH, Folk JE. |
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| Title |
Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization. |
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| Journal |
J. Biol. Chem. 261 (1986) 3085-9. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 101920-83-6 |
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