KEGG   ENZYME: 1.14.99.35Help
Entry
EC 1.14.99.35               Enzyme                                 
Name
thiophene-2-carbonyl-CoA monooxygenase;
thiophene-2-carboxyl-CoA dehydrogenase;
thiophene-2-carboxyl-CoA hydroxylase;
thiophene-2-carboxyl-CoA monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
Miscellaneous
BRITE hierarchy
Sysname
thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase
Reaction(IUBMB)
thiophene-2-carbonyl-CoA + AH2 + O2 = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O [RN:R05742]
Reaction(KEGG)
Substrate
thiophene-2-carbonyl-CoA [CPD:C07347];
AH2 [CPD:C00030];
O2 [CPD:C00007]
Product
5-hydroxythiophene-2-carbonyl-CoA [CPD:C07348];
A [CPD:C00028];
H2O [CPD:C00001]
Comment
A molybdenum enzyme. Highly specific for thiophene-2-carbonyl-CoA. Tetrazolium salts can act as electron acceptors.
Reference
1  [PMID:9531630]
  Authors
Bambauer A, Rainey FA, Stackebrandt E, Winter J.
  Title
Characterization of Aquamicrobium defluvii gen. nov. sp. nov., a thiophene-2-carboxylate-metabolizing bacterium from activated sludge.
  Journal
Arch. Microbiol. 169 (1998) 293-302.
  Organism
Aquamicrobium defluvii
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
208540-44-7
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