KEGG   ENZYME: 1.14.99.39Help
Entry
EC 1.14.99.39               Enzyme                                 
Name
ammonia monooxygenase;
AMO
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
Miscellaneous
BRITE hierarchy
Reaction(IUBMB)
ammonia + AH2 + O2 = NH2OH + A + H2O [RN:R09519]
Reaction(KEGG)
R09519 > R00148;
(other) R09156
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Substrate
ammonia [CPD:C00014];
AH2 [CPD:C00030];
O2 [CPD:C00007]
Product
NH2OH;
A [CPD:C00028];
H2O [CPD:C00001]
Comment
Contains copper and possibly nonheme iron. The donor is membrane-bound. Electrons are derived indirectly from ubiquinol.
Pathway
Nitrogen metabolism
Microbial metabolism in diverse environments
Orthology
K10944  
methane/ammonia monooxygenase subunit A
Genes
MCA: 
MCA1797(pmoA) MCA2854(pmoA2)
MMT: 
MAH: 
NOC: 
NHL: 
NWA: 
NEU: 
NE0944(amoA1) NE2063(amoA2)
NET: 
NIT: 
NII: 
NMU: 
Nmul_A0799 Nmul_A2325 Nmul_A2765
MSC: 
BN69_0203(pmoA2) BN69_2827(pmoA) BN69_3534(pmoA)
MRH: 
MycrhN_3041
MCB: 
Mycch_5910
MIN: 
Minf_1507(pmoA) Minf_1510(pmoA) Minf_1590(pmoA)
MOX: 
DAMO_2450(pmoA)
NMR: 
Nmar_1500
NIR: 
NSED_08255
NKR: 
NKOR_08170
CSY: 
CENSYa_0402
NGA: 
Ngar_c25350(amoA)
 » show all
Taxonomy
Reference
1  [PMID:8085841]
  Authors
Hyman MR, Page CL, Arp DJ
  Title
Oxidation of methyl fluoride and dimethyl ether by ammonia monooxygenase in Nitrosomonas europaea.
  Journal
Appl. Environ. Microbiol. 60 (1994) 3033-5.
  Organism
Nitrosomonas europaea [GN:neu]
Reference
2  [PMID:7980540]
  Authors
Bergmann DJ, Hooper AB
  Title
Sequence of the gene, amoB, for the 43-kDa polypeptide of ammonia monoxygenase of Nitrosomonas europaea.
  Journal
Biochem. Biophys. Res. Commun. 204 (1994) 759-62.
  Organism
Nitrosomonas europaea [GN:neu]
Reference
3  [PMID:7590173]
  Authors
Holmes AJ, Costello A, Lidstrom ME, Murrell JC
  Title
Evidence that particulate methane monooxygenase and ammonia monooxygenase may be  evolutionarily related.
  Journal
FEMS. Microbiol. Lett. 132 (1995) 203-8.
  Organism
Nitrosococcus oceani [GN:noc]
Reference
4  [PMID:8941709]
  Authors
Zahn JA, Arciero DM, Hooper AB, DiSpirito AA
  Title
Evidence for an iron center in the ammonia monooxygenase from Nitrosomonas europaea.
  Journal
FEBS. Lett. 397 (1996) 35-8.
  Organism
Nitrosomonas europaea [GN:neu]
Reference
5  [PMID:8654570]
  Authors
Moir JW, Crossman LC, Spiro S, Richardson DJ
  Title
The purification of ammonia monooxygenase from Paracoccus denitrificans.
  Journal
FEBS. Lett. 387 (1996) 71-4.
  Organism
Paracoccus denitrificans [GN:pde]
Reference
6  [PMID:11004450]
  Authors
Whittaker M, Bergmann D, Arciero D, Hooper AB.
  Title
Electron transfer during the oxidation of ammonia by the chemolithotrophic bacterium Nitrosomonas europaea.
  Journal
Biochim. Biophys. Acta. 1459 (2000) 346-55.
  Organism
Nitrosomonas europaea [GN:neu]
Reference
7  [PMID:12209257]
  Authors
Arp DJ, Sayavedra-Soto LA, Hommes NG.
  Title
Molecular biology and biochemistry of ammonia oxidation by Nitrosomonas europaea.
  Journal
Arch. Microbiol. 178 (2002) 250-5.
  Organism
Nitrosomonas europaea [GN:neu]
Reference
8  [PMID:19453274]
  Authors
Gilch S, Meyer O, Schmidt I
  Title
A soluble form of ammonia monooxygenase in Nitrosomonas europaea.
  Journal
Biol. Chem. 390 (2009) 863-73.
  Organism
Nitrosomonas europaea [GN:neu]
Reference
9  [PMID:2394686]
  Authors
Rasche ME, Hicks RE, Hyman MR, Arp DJ
  Title
Oxidation of monohalogenated ethanes and n-chlorinated alkanes by whole cells of  Nitrosomonas europaea.
  Journal
J. Bacteriol. 172 (1990) 5368-73.
  Organism
Nitrosomonas europaea [GN:neu]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system