KEGG   ENZYME: 1.14.99.4Help
Entry
EC 1.14.99.4                Enzyme                                 
Name
progesterone monooxygenase;
progesterone hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
Miscellaneous
BRITE hierarchy
Sysname
progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
Reaction(IUBMB)
progesterone + AH2 + O2 = testosterone acetate + A + H2O [RN:R02212]
Reaction(KEGG)
Substrate
progesterone [CPD:C00410];
AH2 [CPD:C00030];
O2 [CPD:C00007]
Product
testosterone acetate [CPD:C03027];
A [CPD:C00028];
H2O [CPD:C00001]
Comment
Has a wide specificity. A single enzyme from ascomycete the Neonectria radicicola (EC 1.14.13.54 ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.14.99.12 androst-4-ene-3,17-dione monooxygenase.
Reference
1  [PMID:5950688]
  Authors
Rahm MA, Sih CJ.
  Title
Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain.
  Journal
J. Biol. Chem. 241 (1966) 3615-23.
  Organism
Cladosporium resinae, Cylindrocarpon radicicola
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-85-2
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