KEGG   ENZYME: 1.14.99.44Help
Entry
EC 1.14.99.44               Enzyme                                 

Name
diapolycopene oxygenase;
crtP (ambiguous)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
4,4'-diapolycopene,AH2:oxygen oxidoreductase (4,4'-hydroxylating)
Reaction(IUBMB)
4,4'-diapolycopene + 4 AH2 + 4 O2 = 4,4'-diapolycopenedial + 4 A + 6 H2O [RN:R09671]
Reaction(KEGG)
Substrate
4,4'-diapolycopene [CPD:C19797];
AH2 [CPD:C00030];
O2 [CPD:C00007]
Product
4,4'-diapolycopenedial [CPD:C19798];
A [CPD:C00028];
H2O [CPD:C00001]
Comment
Little activity with neurosporene or lycopene. Involved in the biosynthesis of C30 carotenoids such as staphyloxanthin. The enzyme oxidizes each
methyl group to the hydroxymethyl and then a dihydroxymethyl group,
followed by the spontaneous loss of water to give an aldehyde group.
History
EC 1.14.99.44 created 2011
Pathway
Carotenoid biosynthesis
Orthology
K10210  
diapolycopene oxygenase
Genes
BMH: 
BIF: 
OIH: 
SAU: 
SAV: 
SAW: 
SAH: 
SAJ: 
SAM: 
SAS: 
SAR: 
SAC: 
SAX: 
SAA: 
SAO: 
SAE: 
NWMN_2464(crtI)
SAD: 
SUU: 
SUV: 
SUE: 
SUJ: 
SUK: 
SUC: 
SUT: 
SUQ: 
SUZ: 
MS7_2571(crtP)
SUD: 
SUX: 
SUW: 
SUG: 
SUF: 
SAUA: 
SAUE: 
SAUN: 
SAUS: 
SAUU: 
SAUZ: 
SAB: 
SUY: 
SAUB: 
SAUM: 
SAUC: 
SAUR: 
SAUI: 
SAUT: 
SAUJ: 
SAUK: 
SAUQ: 
SAUV: 
SAUW: 
SAUX: 
SAUY: 
SHA: 
SLG: 
SLN: 
EAT: 
SIV: 
ECAS: 
EMU: 
CRN: 
CAW: 
 » show all
Taxonomy
Reference
1  [PMID:15850982]
  Authors
Mijts BN, Lee PC, Schmidt-Dannert C
  Title
Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution.
  Journal
Chem. Biol. 12 (2005) 453-60.
  Organism
Staphylococcus aureus
  Sequence
[sav:SAV2564]
Reference
2  [PMID:15933032]
  Authors
Tao L, Schenzle A, Odom JM, Cheng Q
  Title
Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde.
  Journal
Appl. Environ. Microbiol. 71 (2005) 3294-301.
  Organism
Staphylococcus aureus
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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