KEGG ENZYME: 1.16.1.1

ENZYME: 1.16.1.1

Entry

EC 1.16.1.1 Enzyme

Name

mercury(II) reductase;
mercuric reductase;
mercurate(II) reductase;
mercuric ion reductase;
mercury reductase;
reduced NADP:mercuric ion oxidoreductase;
mer A

Class

Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor

Sysname

Hg:NADP+ oxidoreductase

Reaction(IUBMB)

Hg + NADP+ + H+ = Hg2+ + NADPH [RN:R02807]

Reaction(KEGG)

R02807

Substrate

Hg [CPD:C01319];
NADP+ [CPD:C00006];
H+ [CPD:C00080]

Product

Hg2+ [CPD:C00703];
NADPH [CPD:C00005]

Comment

A dithiol enzyme.

Orthology

K00520

mercuric reductase

Genes

CME:	CMJ014C
EOI:	ECO111_p1-115
ELO:	EC042_4104(merA)
ELN:	NRG857_30136
ESM:	O3M_00440
ESL:	O3K_00430
EUN:	pUMNK88_146(merA)
STY:	HCM1.158(merA) HCM1.231c(merA)
SEM:	STMDT12_C39370
SEC:	SC020(merA)
SEE:	SNSL254_p_0165(merA)
SEW:	SeSA_B0045(merA)
ENC:	ECL_03824(merA) ECL_A045(merA) ECL_A232(merA)
ESC:	Entcl_2558
EAR:	ST548_p1173 ST548_p1200
KPN:	KPN_pKPN4p07068(merC)
KPM:	KPHS_p200270
ETR:	ETAE_1364
ETD:	ETAF_1269
ETC:	ETAC_06450
XCC:	XCC3891
XCB:	XC_3979
XCA:	xccb100_4081(lpd3)
XCP:	XCR_0386
SML:	Smlt2412(merA)
SMZ:	SMD_1555(merA)
RHD:	R2APBS1_1852 R2APBS1_2075 R2APBS1_2097 R2APBS1_2511 R2APBS1_3814
PPR:	PBPRA2113
PAU:	PA14_15460(merA)
PAP:	PSPA7_0090(merA2) PSPA7_0104(merA1)
PAG:	PLES_26321 PLES_26871(merA)
PNC:	NCGM2_1750
PDK:	PADK2_12170
PPW:	PputW619_2338
PPT:	PPS_5234
PPI:	YSA_03475
PPUH:	B479_00005 B479_27209
PFS:	pQBR0431(merA)
PSA:	PST_1682(lpd3)
PSZ:	PSTAB_1235(merA) PSTAB_1590(lpd)
PSR:	PSTAA_1710(lpd3)
PAR:	Psyc_1392
PCR:	Pcryo_0977
ABY:	ABAYE3605(merA)
ABN:	AB57_0271(merA)
ABX:	ABK1_1138
SFR:	Sfri_2957 Sfri_3488
SPC:	Sputcn32_0168
SHP:	Sput200_3755
SHN:	Shewana3_4311 Shewana3_4345
SHW:	Sputw3181_3208
SWD:	Swoo_2443
ILO:	IL1160(merA_1) IL1646(merA_2)
PHA:	PSHAb0231
PAT:	Patl_0395
PSM:	PSM_B0282
SDE:	Sde_3653
MAQ:	Maqu_0145 Maqu_0242 Maqu_4010
MHC:	MARHY0139 MARHY1938(merA)
MAD:	HP15_194 HP15_3849
MBS:	MRBBS_0156(merA) MRBBS_0169(lpdA)
AMC:	MADE_1005505 MADE_1005590 MADE_1009060
AMAC:	MASE_08255
AMB:	AMBAS45_08845
AMG:	AMEC673_08350
AMAA:	amad1_09425 amad1_14695
ALT:	ambt_06820
GAG:	Glaag_0470 Glaag_4409
GNI:	GNIT_0094(merA)
GPS:	C427_5496
PIN:	Ping_2767
LPN:	lpg0244 lpg1562(merA1) lpg2101(merA1)
LPU:	LPE509_01004 LPE509_01639
LPF:	lpl1464
LPP:	lpp1519
LPC:	LPC_0984(merA1)
LPA:	lpa_02267
LPE:	lp12_1500 lp12_2042
MCA:	MCA1340(merA)
MMT:	Metme_3567
MAH:	MEALZ_1382
FTG:	FTU_1532(merA)
FTL:	FTL_0277
FTH:	FTH_0276
FTA:	FTA_0294
FTS:	F92_01500
FTI:	FTS_0273
FTM:	FTM_0381
FTN:	FTN_1526
FCF:	FNFX1_1564
FCN:	FN3523_1589
FPH:	Fphi_1113
FRT:	F7308_0713
FNA:	OOM_0702
CYQ:	Q91_1005
NOC:	Noc_0589 Noc_2758
NHL:	Nhal_1676 Nhal_2940
NWA:	Nwat_2070
AEH:	Mlg_0751
TGR:	Tgr7_1070
TKM:	TK90_0910
TNI:	TVNIR_0332(ykgC_[H]) TVNIR_2229(merA_[H])
HNA:	Hneap_1209
HCH:	HCH_01003
CSA:	Csal_3219
HEL:	HELO_4098
ABO:	ABO_2183
ADI:	B5T_00802
KKO:	Kkor_1269
MMW:	Mmwyl1_0176
MME:	Marme_3846
MPC:	Mar181_0131
AHA:	AHA_1547 AHA_3827
ASA:	ASA_2809 ASA_P4G091(merA)
AVR:	B565_2651
TAU:	Tola_0994
OCE:	GU3_06850
AFE:	Lferr_2107
AFR:	AFE_2481(merA)
ACU:	Atc_1058
AFI:	Acife_0787 Acife_2290
SAGA:	M5M_11360
RSO:	RS02078(RSp1380)
RSL:	RPSI07_mp1359
RSN:	RSPO_m00688(lpdA)
RPI:	Rpic_1787 Rpic_3897
RPF:	Rpic12D_4011
REU:	Reut_A0385 Reut_D6495
REH:	H16_B1765
RME:	Rmet_5011 Rmet_6174(merA) Rmet_6183(merA)
CNC:	CNE_2c17120
BPS:	BPSS0139
BPM:	BURPS1710b_A1652(lpd)
BPL:	BURPS1106A_A0194
BPD:	BURPS668_A0283
BPZ:	BP1026B_II0157
BPQ:	BPC006_II0185
BVI:	Bcep1808_4083
BUR:	Bcep18194_B2463
BCN:	Bcen_4715
BCH:	Bcen2424_3648
BCM:	Bcenmc03_3872
BCJ:	BCAM0684
BAM:	Bamb_5390
BAC:	BamMC406_3551
BMU:	Bmul_5056
BMJ:	BMULJ_03460(merA)
BCT:	GEM_5113
BXE:	Bxe_A1496 Bxe_C1213
BPH:	Bphy_1496 Bphy_6297
BPY:	Bphyt_2630
BGL:	bglu_2p0780 bglu_2p0980
BUG:	BC1001_2334
BGE:	BC1002_1929
BGF:	BC1003_1127
BGD:	bgla_1g28550
BYI:	BYI23_A014720 BYI23_C007010 BYI23_E002730(merA)
BUK:	MYA_3771
BPX:	BUPH_02911
AXY:	AXYL_01070(merA)
PUT:	PT7_0583
RFR:	Rfer_1621
POL:	Bpro_1509 Bpro_2228
AJS:	Ajs_1298
DIA:	Dtpsy_1158 Dtpsy_2133
ACK:	C380_05680
DAC:	Daci_0483
VAP:	Vapar_5924
ADN:	Alide_1826 Alide_4499
ADK:	Alide2_1949
RTA:	Rta_03980
MMS:	mma_0954 mma_1749(merA)
LCH:	Lcho_1709
TIN:	Tint_1608
THI:	THI_1799(merA1) THI_3072(merA2)
NEU:	NE0839(merA)
NET:	Neut_1309 Neut_2567
NIT:	NAL212_0101 NAL212_1630
NII:	Nit79A3_2350
EBA:	ebA4535 ebA6707(merA)
TMZ:	Tmz1t_3558
DSU:	Dsui_2497
TBD:	Tbd_1341 Tbd_1472
APP:	CAP2UW1_2826
GCA:	Galf_1900 Galf_1915
GSU:	GSU1315(lpdA-4) GSU3424(lpdA-3)
GSK:	KN400_1288 KN400_3368
GME:	Gmet_0177(lpdA-3)
GUR:	Gura_0840 Gura_3749
GLO:	Glov_1982
GBM:	Gbem_0457 Gbem_0640
GEO:	Geob_1001
GEM:	GM21_0473 GM21_0654
GEB:	GM18_3713 GM18_3922
PCA:	Pcar_2535(lpdA-4)
DVU:	DVU1037
DVL:	Dvul_1956
DVM:	DvMF_0898
DVG:	Deval_0956
DDE:	Dde_1463
DMA:	DMR_34970(merA)
DSA:	Desal_2458
DAF:	Desaf_0086
DHY:	DESAM_22597
DPI:	BN4_10229(gidA)
DBA:	Dbac_0341
DRT:	Dret_1498
BMX:	BMS_0437
DPS:	DP0504
DAK:	DaAHT2_0677
DSF:	UWK_01346
DOL:	Dole_1598
DAL:	Dalk_3001
DAT:	HRM2_06210
DTO:	TOL2_C02510
ADE:	Adeh_2206
ACP:	A2cp1_1741
AFW:	Anae109_3623
ANK:	AnaeK_1668
SCL:	sce2324
HOH:	Hoch_6515
DTI:	Desti_3189
DBR:	Deba_0693
HMR:	Hipma_0389
MLO:	mll5241 mlr2769
MCI:	Mesci_0271 Mesci_2104
MOP:	Mesop_0257 Mesop_2221
MAM:	Mesau_00259 Mesau_02137
MES:	Meso_0352
PLA:	Plav_0304
SME:	SM_b21143(merA2) SMc01717(merA1)
SMK:	Sinme_0082 Sinme_4895
SMQ:	SinmeB_0082 SinmeB_3855
SMX:	SM11_chr0082(merA1) SM11_pD0785(merA2)
SMI:	BN406_00080(merA1) BN406_05848
SMEG:	C770_GR4Chr0457 C770_GR4pD0769
SMEL:	SM2011_b21143(merA2) SM2011_c01717(merA1)
SMD:	Smed_0084 Smed_4636
RHI:	NGR_b12970 NGR_c00870
SFH:	SFHH103_00087(merA1) SFHH103_05757
SFD:	USDA257_c00830(merA) USDA257_c10110(ykgC)
ATU:	Atu5537
RET:	RHE_PE00270
REC:	RHECIAT_PA0000215
RLE:	pRL110384
RLT:	Rleg2_5831
RLG:	Rleg_6744
RTR:	RTCIAT899_PC00060
BBT:	BBta_3385
OCA:	OCAR_7751(merA)
OCG:	OCA5_pOC16700650(merA)
OCO:	OCA4_pOC167B00650(merA)
SNO:	Snov_2041
MEA:	Mex_1p2635(merA)
MRD:	Mrad2831_1270 Mrad2831_2549
MNO:	Mnod_3669
MSL:	Msil_2876
HDN:	Hden_3424
HMC:	HYPMC_4019 HYPMC_4869 HYPMC_4874
RVA:	Rvan_2393
PHL:	KKY_75 KKY_966
CAK:	Caul_4997
CSE:	Cseg_1903
SIL:	SPO0540
SIT:	TM1040_0315
RSP:	RSP_1057(merA1)
RSH:	Rsph17029_2718
RSQ:	Rsph17025_0072
RSK:	RSKD131_2451
JAN:	Jann_0645
RDE:	RD1_1463(merA) RD1_1464(merA)
RLI:	RLO149_c033200(lpd3)
DSH:	Dshi_0335(merA)
PSF:	PSE_1104
PGA:	PGA1_c02180(lpdA1)
PGL:	PGA2_c28710(lpdA2)
OAT:	OAN307_c17630(merA1) OAN307_c31790(merA2) OAN307_c43700(lpd3)
OAR:	OA238_c36450(lpdA3) OA238_c45600(merA)
MMR:	Mmar10_2329
HNE:	HNE_0408 HNE_1691(merA)
HBA:	Hbal_0885
SAL:	Sala_2512 Sala_2683 Sala_2701
SPHM:	G432_19365
SSY:	SLG_07530 SLG_p_00120(merA)
ELI:	ELI_00350
ACR:	Acry_0193 Acry_3132
AMV:	ACMV_02180 ACMV_26480(merA) ACMV_P1_00190(merA)
GXY:	GLX_31490
RCE:	RC1_2279(merA)
TMO:	TMO_2719(merA) TMO_c0073(merA)
PBR:	PB2503_12389 PB2503_13164
APB:	SAR116_1324
PGV:	SL003B_3630
DIN:	Selin_0314
BSUB:	BEST7613_1865(merA)
BCU:	BCAH820_4533(merA)
BPF:	BpOF4_20564
BSE:	Bsel_0467
BCO:	Bcell_3089
BCK:	BCO26_1334
GKA:	GK3096
GTE:	GTCCBUS3UF5_34710
GYC:	GYMC61_3185
GYA:	GYMC52_3214
GCT:	GC56T3_3124
AFL:	Aflv_1424(merA)
SUW:	SATW20_00600(merA)
SAB:	SAB0544c
SEP:	SE0085
HHD:	HBHAL_2132
EAT:	EAT1b_2015
EAN:	Eab7_2694
BTS:	Btus_2787
SAG:	SAG1254(merA-1) SAG2023(merA-2)
SGO:	SGO_0368(merA)
SMB:	smi_0886(merA)
TMR:	Tmar_1608
SAY:	TPY_3741(merA)
SAP:	Sulac_3436
HAS:	Halsa_1286
HPK:	Hprae_0999
MSY:	MS53_0152
ACL:	ACL_0780(merA)
MPA:	MAP1844c(lpd)
MAV:	MAV_2396
MIT:	OCO_23960
MIR:	OCQ_22490
MIA:	OCU_23840
MID:	MIP_03310
MSG:	MSMEI_4080
MSA:	Mycsm_03631 Mycsm_03783
MVA:	Mvan_3468
MGI:	Mflv_3059 Mflv_3213
MSP:	Mspyr1_25000
MAB:	MAB_p06
MMV:	MYCMA_1662(ykgC)
MMC:	Mmcs_3142
MKM:	Mkms_3204
MJL:	Mjls_3154
MMI:	MMAR_3101(lpd_1) MMAR_p12(merA)
MRH:	MycrhN_5119
MMM:	W7S_11555
MCB:	Mycch_3118 Mycch_5491 Mycch_5643 Mycch_5854
MLI:	MULP_03360(lpd_1)
ASD:	AS9A_4153
CGL:	NCgl2908(Cgl3011)
CGB:	cg3339(merA)
CGT:	cgR_0163
CDE:	CDHC02_0068(merA)
CDZ:	CD31A_0067(merA)
CDB:	CDBH8_0070(merA)
CDW:	CDPW8_0062(merA)
CJK:	jk1442(merA)
CUR:	cur_0632
CUA:	CU7111_0621(merA)
GBR:	Gbro_2649
SCO:	SCO3443(SCE36.10c) SCO3460(SCE46.17)
SVL:	Strvi_1278
SCT:	SCAT_3671
SCY:	SCATT_36620
ART:	Arth_1778 Arth_4196 Arth_4296 Arth_4465
AAU:	AAur_pTC10241(merA)
ACH:	Achl_4511
APN:	Asphe3_40770 Asphe3_41570
ARR:	ARUE_232p00800(merA)
MLU:	Mlut_06150
JDE:	Jden_0072
KSE:	Ksed_25620
CFL:	Cfla_3663
CFI:	Celf_3663
CGA:	Celgi_2803
ICA:	Intca_0191
MPH:	MLP_04940
NCA:	Noca_4946
ACE:	Acel_0690
BSD:	BLASA_1862(merA) BLASA_4779
SEN:	SACE_3455
AMD:	AMED_3505(pdhD)
PDX:	Psed_1277 Psed_1294 Psed_1317 Psed_4322 Psed_6715 Psed_6722
STP:	Strop_4228
SAQ:	Sare_4668 Sare_4957
MAU:	Micau_0248
MIL:	ML5_0232 ML5_4212
VMA:	VAB18032_07470
AMS:	AMIS_1500
ASE:	ACPL_258
SNA:	Snas_1334 Snas_5372
RXY:	Rxyl_1767
CWO:	Cwoe_2170
AFO:	Afer_2009
AYM:	YM304_24810
PUV:	PUV_12060(merA)
SNG:	SNE_A18680 SNE_B24430(merA)
TPX:	Turpa_3476
ABA:	Acid345_0840
ACA:	ACP_2726
ACM:	AciX9_2665
GMA:	AciX8_1147 AciX8_1736
TSA:	AciPR4_4069
TRS:	Terro_0228
SUS:	Acid_4230
CTM:	Cabther_B0625
SRU:	SRU_0077 SRU_2392
SRM:	SRM_00082(merA) SRM_02611(merA)
RMR:	Rmar_1388
RMG:	Rhom172_1443
CPI:	Cpin_4961
NKO:	Niako_4204
SHG:	Sph21_2569
CMR:	Cycma_1260 Cycma_4530
BBD:	Belba_2845
EVI:	Echvi_0722 Echvi_4481
DFE:	Dfer_1248
FLI:	Fleli_0702
FAE:	FAES_1313(merA1) FAES_1547(merA3)
GFO:	GFO_1127(merA)
ZPR:	ZPR_4025
OHO:	Oweho_2056 Oweho_2923
FNU:	FN0820
IPO:	Ilyop_2655
OTE:	Oter_0309 Oter_2746
CAA:	Caka_0673
MIN:	Minf_0451
RBA:	RB11205(merA)
PSL:	Psta_0242
IPA:	Isop_3509
SACI:	Sinac_3751 Sinac_5065
SYN:	slr1849(merA)
SYZ:	MYO_15110(merA)
SYY:	SYNGTS_0505(merA)
SYT:	SYNGTI_0505(merA)
SYS:	SYNPCCN_0505(merA)
SYQ:	SYNPCCP_0505(merA)
SYC:	syc0431_d
SYF:	Synpcc7942_1118
SYP:	SYNPCC7002_A1295(merA1)
SYNE:	Syn6312_3428
SYNP:	Syn7502_00891
MAR:	MAE_22610
CYT:	cce_0856(merA)
CYP:	PCC8801_0936
CYC:	PCC7424_4940
CYN:	Cyan7425_1976
CYH:	Cyan8802_0963
CYJ:	Cyan7822_3808
AMR:	AM1_0141
CGC:	Cyagr_0399 Cyagr_2508
CAN:	Cyan10605_0803
CSN:	Cyast_2351
DSL:	Dacsa_2023
HAO:	PCC7418_3088
GLP:	Glo7428_3317
CMP:	Cha6605_0377
GVI:	gll0564 glr2871
ANA:	all5185
NPU:	Npun_BR178 Npun_R3470
NOS:	Nos7107_5073
NOP:	Nos7524_2103
AVA:	Ava_2431
ANB:	ANA_C10952
ACY:	Anacy_5321
NAZ:	Aazo_1429
CSG:	Cylst_0111
CALO:	Cal7507_3770
CALT:	Cal6303_0100
RIV:	Riv7116_5630
TER:	Tery_3348
LEP:	Lepto7376_0981
GEI:	GEI7407_0617
OAC:	Oscil6304_2764
ONI:	Osc7112_2557 Osc7112_2732
PSEU:	Pse7367_0134
CEP:	Cri9333_4334
MIC:	Mic7113_5098
ARP:	NIES39_D00130
CTHE:	Chro_3323
PLP:	Ple7327_0236
SCS:	Sta7437_4363
CPB:	Cphamn1_1481
PAA:	Paes_1239
IAL:	IALB_1950(merA)
DET:	DET0732
DEH:	cbdb_A687
DEB:	DehaBAV1_0664
DEV:	DhcVS_638
DEG:	DehalGT_0625
DMC:	btf_654
DMD:	dcmb_700
DLY:	Dehly_0622 Dehly_0848
RRS:	RoseRS_3142
HAU:	Haur_3049
TRO:	trd_A0380(merA)
CAP:	CLDAP_38310
DDR:	Deide_1p00160
DPD:	Deipe_0655 Deipe_4201 Deipe_4340
TRA:	Trad_1459
TTH:	TTC0789
TTJ:	TTHA1153
TTS:	Ththe16_1165
TTL:	TtJL18_0903
MSV:	Mesil_1148
OPR:	Ocepr_0477
MHD:	Marky_0687 Marky_2015 Marky_2019
HYA:	HY04AAS1_1213
HTH:	HTH_1325(merA)
HTE:	Hydth_1316
MPG:	Theba_2469
NDE:	NIDE1146
LFC:	LFE_0160 LFE_0726
LFI:	LFML04_0795 LFML04_1899(merA)
TTR:	Tter_2086
DDF:	DEFDS_0908
DAP:	Dacet_1398
FSI:	Flexsi_2048
HMA:	pNG6156(merA)
HLA:	Hlac_2847 Hlac_2992 Hlac_2994
NPE:	Natpe_4217
TAC:	Ta1341
TVO:	TVN0251
PTO:	PTO0264
APE:	APE_1458
SSO:	SSO2689(merA)
SOL:	Ssol_0504
STO:	ST1075
SAI:	Saci_1708(merA)
SACN:	SacN8_08295
SACR:	SacRon12I_08305
SII:	LD85_2941
SIH:	SiH_2567
SIR:	SiRe_2510
SIC:	SiL_2462
MSE:	Msed_1241
MCN:	Mcup_1326
AHO:	Ahos_1711
PAI:	PAE2623
PCL:	Pcal_1459
PAS:	Pars_1205
PYR:	P186_1796
CMA:	Cmaq_1504
TUZ:	TUZN_1009
TTN:	TTX_0406(lpd-2)
VDI:	Vdis_1369
CLG:	Calag_0616
NGA:	Ngar_c19680(merA1) Ngar_c27380(merA2)
HAH:	Halar_0455 Halar_1060 Halar_1062

» show all

Reference

1 [PMID:6277900]

Authors

Fox B, Walsh CT.

Title

Mercuric reductase. Purification and characterization of a transposon-encoded flavoprotein containing an oxidation-reduction-active disulfide.

Journal

J. Biol. Chem. 257 (1982) 2498-503.

Organism

Pseudomonas aeruginosa

Reference

2 [PMID:6412751]

Authors

Fox BS, Walsh CT.

Title

Mercuric reductase: homology to glutathione reductase and lipoamide dehydrogenase. Iodoacetamide alkylation and sequence of the active site peptide.

Journal

Biochemistry. 22 (1983) 4082-8.

Organism

Pseudomonas aeruginosa

Other DBs

ExplorEnz - The Enzyme Database:

1.16.1.1

IUBMB Enzyme Nomenclature:

1.16.1.1

ExPASy - ENZYME nomenclature database:

1.16.1.1

UM-BBD (Biocatalysis/Biodegradation Database):

1.16.1.1

BRENDA, the Enzyme Database:

1.16.1.1

CAS:

67880-93-7

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Ontology (1)   
   KEGG BRITE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RPAIR (2)   
Gene (7476)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (683)   
   KEGG EGENES (10)   
   KEGG MGENES (6782)   
Protein sequence (1202)   
   UniProt (578)   
   PRF (29)   
   RefSeq(pep) (590)   
   PDBSTR (4)   
   PMD (1)   
DNA sequence (1081)   
   RefSeq(nuc) (546)   
   GenBank (266)   
   EMBL (269)   
3D Structure (4)   
   PDB (4)   
Protein domain (4)   
   InterPro (2)   
   PROSITE(DOC) (2)   
Literature (2)   
   PubMed (2)   
Enzyme (5)   
   BRENDA (1)   
   EXPASY-ENZYME (1)   
   EXPLORENZ (1)   
   IUBMB (1)   
   UMBBD-EC (1)   
All databases (9783)   

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