KEGG   ENZYME: 1.16.1.10Help
Entry
EC 1.16.1.10                Enzyme                                 

Name
ferric-chelate reductase [NAD(P)H];
ferric reductase (ambiguous)
Class
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
Fe(II)-siderophore:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2 Fe(II)-siderophore + NAD(P)+ + H+ = 2 Fe(III)-siderophore + NAD(P)H
Substrate
Fe(II)-siderophore;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H+ [CPD:C00080]
Product
Fe(III)-siderophore;
NADH [CPD:C00004];
NADPH [CPD:C00005]
Comment
A flavoprotein. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III). cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.9, ferric-chelate reductase (NADPH).
History
EC 1.16.1.10 created 2014
Orthology
K18915  
ferric-chelate reductase [NAD(P)H]
Genes
AFU: 
AFG: 
AST: 
FPL: 
Taxonomy
Reference
1  [PMID:10593977]
  Authors
Vadas A, Monbouquette HG, Johnson E, Schroder I
  Title
Identification and characterization of a novel ferric reductase from the hyperthermophilic Archaeon Archaeoglobus fulgidus.
  Journal
J. Biol. Chem. 274 (1999) 36715-21.
  Sequence
[afu:AF_0830]
Reference
2  [PMID:11525168]
  Authors
Chiu HJ, Johnson E, Schroder I, Rees DC
  Title
Crystal structures of a novel ferric reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus and its complex with NADP+.
  Journal
Structure. 9 (2001) 311-9.
  Sequence
[afu:AF_0830]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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