KEGG   ENZYME: 1.16.1.4Help
Entry
EC 1.16.1.4                 Enzyme                                 

Name
cob(II)alamin reductase;
vitamin B12r reductase;
B12r reductase;
NADH2:cob(II)alamin oxidoreductase
Class
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
cob(I)alamin:NAD+ oxidoreductase
Reaction(IUBMB)
2 cob(I)alamin + NAD+ = 2 cob(II)alamin + NADH + H+ [RN:R00099]
Reaction(KEGG)
Substrate
cob(I)alamin [CPD:C00853];
NAD+ [CPD:C00003]
Product
cob(II)alamin [CPD:C00541];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
A flavoprotein.
History
EC 1.16.1.4 created 1972 as EC 1.6.99.9, transferred 2002 to EC 1.16.1.4
Pathway
Porphyrin and chlorophyll metabolism
Reference
1  [PMID:4390543]
  Authors
Walker GA, Murphy S, Huennekens FM.
  Title
Enzymatic conversion of vitamin B 12a to adenosyl-B 12: evidence for the existence of two separate reducing systems.
  Journal
Arch. Biochem. Biophys. 134 (1969) 95-102.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-40-9

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