KEGG   ENZYME: 1.16.1.5Help
Entry
EC 1.16.1.5                 Enzyme                                 

Name
aquacobalamin reductase (NADPH);
aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase;
NADPH-linked aquacobalamin reductase;
NADPH2:aquacob(III)alamin oxidoreductase
Class
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
cob(II)alamin:NADP+ oxidoreductase
Reaction(IUBMB)
2 cob(II)alamin + NADP+ + 2 H2O = 2 aquacob(III)alamin + NADPH + H+ [RN:R00107]
Reaction(KEGG)
Substrate
cob(II)alamin [CPD:C00541];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
aquacob(III)alamin [CPD:C00992];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A flavoprotein. Acts on aquacob(III)alamin and hydroxycobalamin, but not on cyanocobalamin.
History
EC 1.16.1.5 created 1989 as EC 1.6.99.11, transferred 2002 to EC 1.16.1.5
Pathway
Porphyrin and chlorophyll metabolism
Metabolic pathways
Reference
1  [PMID:3114247]
  Authors
Watanabe F, Oki Y, Nakano Y, Kitaoka S.
  Title
Purification and characterization of aquacobalamin reductase (NADPH) from Euglena gracilis.
  Journal
J. Biol. Chem. 262 (1987) 11514-8.
Reference
2  [PMID:8373179]
  Authors
Watanabe F, Yamaji R, Isegawa Y, Yamamoto T, Tamura Y, Nakano Y.
  Title
Characterization of aquacobalamin reductase (NADPH) from Euglena gracilis.
  Journal
Arch. Biochem. Biophys. 305 (1993) 421-7.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
110777-32-7

DBGET integrated database retrieval system