Entry |
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Name |
aquacobalamin reductase (NADPH);
aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase;
NADPH-linked aquacobalamin reductase;
NADPH2:aquacob(III)alamin oxidoreductase
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Class |
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
 |
Sysname |
cob(II)alamin:NADP+ oxidoreductase
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Reaction(IUBMB) |
2 cob(II)alamin + NADP+ + 2 H2O = 2 aquacob(III)alamin + NADPH + H+ [RN: R00107]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
A flavoprotein. Acts on aquacob(III)alamin and hydroxycobalamin, but not on cyanocobalamin.
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History |
EC 1.16.1.5 created 1989 as EC 1.6.99.11, transferred 2002 to EC 1.16.1.5
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Pathway |
ec00860 | Porphyrin and chlorophyll metabolism |
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Orthology |
K21682 | pyruvate dehydrogenase (NADP+) / aquacobalamin reductase (NADPH) |
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Genes |
 |
Reference |
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Authors |
Watanabe F, Oki Y, Nakano Y, Kitaoka S. |
Title |
Purification and characterization of aquacobalamin reductase (NADPH) from Euglena gracilis. |
Journal |
J. Biol. Chem. 262 (1987) 11514-8. |
Reference |
|
Authors |
Watanabe F, Yamaji R, Isegawa Y, Yamamoto T, Tamura Y, Nakano Y. |
Title |
Characterization of aquacobalamin reductase (NADPH) from Euglena gracilis. |
Journal |
Arch. Biochem. Biophys. 305 (1993) 421-7. |
Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.16.1.5 |
ExPASy - ENZYME nomenclature database: | 1.16.1.5 |
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