KEGG   ENZYME: 1.16.1.7Help
Entry
EC 1.16.1.7                 Enzyme                                 

Name
ferric-chelate reductase (NADH);
ferric chelate reductase (ambiguous);
iron chelate reductase (ambiguous);
NADH:Fe3+-EDTA reductase;
NADH2:Fe3+ oxidoreductase;
ferB (gene name);
Fe(II):NAD+ oxidoreductase
Class
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
Fe(II)-siderophore:NAD+ oxidoreductase
Reaction(IUBMB)
2 Fe(II)-siderophore + NAD+ + H+ = 2 Fe(III)-siderophore + NADH [RN:R00092]
Reaction(KEGG)
Substrate
Fe(II)-siderophore;
NAD+ [CPD:C00003];
H+ [CPD:C00080]
Product
Fe(III)-siderophore;
NADH [CPD:C00004]
Comment
Contains FAD. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The plant enzyme is involved in the transport of iron across plant plasma membranes. The enzyme from the bacterium Paracoccus denitrificans can also reduce chromate. cf. EC 1.16.1.9, ferric-chelate reductase (NADPH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H].
History
EC 1.16.1.7 created 1992 as EC 1.6.99.13, transferred 2002 to EC 1.16.1.7, modified 2011, modified 2014
Orthology
K00521  
ferric-chelate reductase
Genes
SCE: 
YLL051C(FRE6) YNR060W(FRE4) YOL152W(FRE7) YOR381W(FRE3) YOR384W(FRE5)
AGO: 
KLA: 
CGR: 
PPA: 
PIC: 
PICST_40289(FRE1.2)
CDU: 
NCR: 
PAN: 
MGR: 
NHE: 
MAW: 
MAJ: 
SSL: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_606034(AO090103000367)
ANG: 
ANI_1_1820064(An07g05510)
AFV: 
ACT: 
NFI: 
PCS: 
CPW: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
CNE: 
UMA: 
 » show all
Taxonomy
Reference
1
  Authors
Askerlund, P., Larrson, C. and Widell, S.
  Title
Localization of donor and acceptor sites of NADH dehydrogenase activities using inside-out and right-side-out plasma membrane vesicles from plants.
  Journal
FEBS Lett. 239 (1988) 23-28.
Reference
2
  Authors
Bruggemann, W. and Moog, P.R.
  Title
NADH-dependent Fe3+ EDTA and oxygen reduction by plasma membrane vesicles from barley roots.
  Journal
Physiol. Plant. 75 (1989) 245-254.
Reference
3
  Authors
Bruggemann, W., Moog, P.R., Nakagawa, H., Janiesch, P. and Kuiper, P.J.C.
  Title
Plasma membrane-bound NADH:Fe3+-EDTA reductase and iron deficiency in tomato (Lycopersicon esculentum). Is there a Turbo reductase ?.
  Journal
Physiol. Plant. 79 (1990) 339-346.
Reference
4
  Authors
Buckhout, T.J. and Hrubec, T.C.
  Title
Pyridine nucleotide-dependent ferricyanide reduction associated with isolated plasma membranes of maize (Zea mays L.) roots.
  Journal
Protoplasma 135 (1986) 144-154.
Reference
5
  Authors
Sandelius, A.S., Barr, R., Crane, F.L. and Morre, D.J.
  Title
Redox reactions of plasma membranes isolated from soybean hypocotyls by phase partition.
  Journal
Plant Sci. 48 (1986) 1-10.
Reference
6  [PMID:14728682]
  Authors
Mazoch J, Tesarik R, Sedlacek V, Kucera I, Turanek J
  Title
Isolation and biochemical characterization of two soluble iron(III) reductases from Paracoccus denitrificans.
  Journal
Eur. J. Biochem. 271 (2004) 553-62.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
120720-17-4

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