KEGG   ENZYME: 1.16.1.7Help
Entry
EC 1.16.1.7                 Enzyme                                 

Name
ferric-chelate reductase (NADH);
ferric chelate reductase (ambiguous);
iron chelate reductase (ambiguous);
NADH:Fe3+-EDTA reductase;
NADH2:Fe3+ oxidoreductase;
ferB (gene name);
Fe(II):NAD+ oxidoreductase
Class
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
Fe(II)-siderophore:NAD+ oxidoreductase
Reaction(IUBMB)
2 Fe(II)-siderophore + NAD+ + H+ = 2 Fe(III)-siderophore + NADH [RN:R00092]
Reaction(KEGG)
Substrate
Fe(II)-siderophore;
NAD+ [CPD:C00003];
H+ [CPD:C00080]
Product
Fe(III)-siderophore;
NADH [CPD:C00004]
Comment
Contains FAD. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The plant enzyme is involved in the transport of iron across plant plasma membranes. The enzyme from the bacterium Paracoccus denitrificans can also reduce chromate. cf. EC 1.16.1.9, ferric-chelate reductase (NADPH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H].
History
EC 1.16.1.7 created 1992 as EC 1.6.99.13, transferred 2002 to EC 1.16.1.7, modified 2011, modified 2014
Orthology
K00521  ferric-chelate reductase
Genes
ATH: AT1G01580(FRO2) AT1G01590(FRO1) AT1G23020(FRO3) AT5G23980(FRO4) AT5G23990(FRO5) AT5G49730(FRO6) AT5G49740(FRO7) AT5G50160(FRO8)
ALY: ARALYDRAFT_470119 ARALYDRAFT_472552 ARALYDRAFT_495072 ARALYDRAFT_662212 ARALYDRAFT_662213 ARALYDRAFT_677744 ARALYDRAFT_912220 ARALYDRAFT_917971 ARALYDRAFT_917972
CRB: 111832573 17875486 17876579 17881311 17883727 17900195 17900764
CSAT: 104706695 104709065 104711774 104724271 104724294 104725473 104725475 104725524 104736410 104737747 104738638 104741016 104743100 104752049 104754307 104754309 104756660 104758853 104760957 104760958 104761003 104770770 104776424 104778516 109125083
EUS: EUTSA_v10003544mg EUTSA_v10006930mg EUTSA_v10006972mg EUTSA_v10012790mg EUTSA_v10012839mg EUTSA_v10028469mg
BRP: 103835570 103836963 103840187 103843795 103843797 103843890 103844661 103854878 103874261
BNA: 106352010 106370060 106377370 106377373 106378613 106380097 106395200 106425673 106430647 106433706 106434146 106434184 106434186 106434937 106435186 106437481 106452002
BOE: 106293244 106307452 106311524 106314038 106318432 106326287 106343163
THJ: 104800318 104809245 104818163 104825852
CPAP: 110810118 110810296 110810297 110819635 110819752 110820914 110820952
LJA: Lj0g3v0104999.1(Lj0g3v0104999.1) Lj0g3v0105009.1(Lj0g3v0105009.1) Lj0g3v0268429.1(Lj0g3v0268429.1) Lj0g3v0360999.1(Lj0g3v0360999.1) Lj0g3v0360999.2(Lj0g3v0360999.2) Lj4g3v0072190.1(Lj4g3v0072190.1) Lj4g3v0072240.1(Lj4g3v0072240.1) Lj4g3v1440660.1(Lj4g3v1440660.1) Lj5g3v1988770.1(Lj5g3v1988770.1) Lj5g3v1988770.2(Lj5g3v1988770.2) Lj6g3v1693230.1(Lj6g3v1693230.1) Lj6g3v1693290.1(Lj6g3v1693290.1)
DOSA: Os04t0444800-01(Os04g0444800) Os04t0578600-01(Os04g0578600)
OBR: 102708713
ATS: 109733798(LOC109733798) 109759862(LOC109759862)
SBI: 8080358
ZMA: 100281526
SITA: 101763321
SMIN: v1.2.005108.t1(symbB.v1.2.005108.t1)
 » show all
Taxonomy
Reference
1
  Authors
Askerlund, P., Larrson, C. and Widell, S.
  Title
Localization of donor and acceptor sites of NADH dehydrogenase activities using inside-out and right-side-out plasma membrane vesicles from plants.
  Journal
FEBS Lett. 239 (1988) 23-28.
Reference
2
  Authors
Bruggemann, W. and Moog, P.R.
  Title
NADH-dependent Fe3+ EDTA and oxygen reduction by plasma membrane vesicles from barley roots.
  Journal
Physiol. Plant. 75 (1989) 245-254.
Reference
3
  Authors
Bruggemann, W., Moog, P.R., Nakagawa, H., Janiesch, P. and Kuiper, P.J.C.
  Title
Plasma membrane-bound NADH:Fe3+-EDTA reductase and iron deficiency in tomato (Lycopersicon esculentum). Is there a Turbo reductase ?.
  Journal
Physiol. Plant. 79 (1990) 339-346.
Reference
4
  Authors
Buckhout, T.J. and Hrubec, T.C.
  Title
Pyridine nucleotide-dependent ferricyanide reduction associated with isolated plasma membranes of maize (Zea mays L.) roots.
  Journal
Protoplasma 135 (1986) 144-154.
Reference
5
  Authors
Sandelius, A.S., Barr, R., Crane, F.L. and Morre, D.J.
  Title
Redox reactions of plasma membranes isolated from soybean hypocotyls by phase partition.
  Journal
Plant Sci. 48 (1986) 1-10.
Reference
6  [PMID:14728682]
  Authors
Mazoch J, Tesarik R, Sedlacek V, Kucera I, Turanek J
  Title
Isolation and biochemical characterization of two soluble iron(III) reductases from Paracoccus denitrificans.
  Journal
Eur. J. Biochem. 271 (2004) 553-62.
Other DBs
ExplorEnz - The Enzyme Database: 1.16.1.7
IUBMB Enzyme Nomenclature: 1.16.1.7
ExPASy - ENZYME nomenclature database: 1.16.1.7
BRENDA, the Enzyme Database: 1.16.1.7
CAS: 120720-17-4

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