KEGG   ENZYME: 1.16.8.1Help
Entry
EC 1.16.8.1                 Enzyme                                 

Name
cob(II)yrinic acid a,c-diamide reductase;
cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect)
Class
Oxidoreductases;
Oxidizing metal ions;
With a flavin as acceptor
BRITE hierarchy
Sysname
cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase
Reaction(IUBMB)
2 cob(I)yrinic acid a,c-diamide + FMN + 2 H+ = 2 cob(II)yrinic acid a,c-diamide + FMNH2 [RN:R05218]
Reaction(KEGG)
Substrate
cob(I)yrinic acid a,c-diamide [CPD:C06505];
FMN [CPD:C00061];
H+ [CPD:C00080]
Product
cob(II)yrinic acid a,c-diamide [CPD:C06504];
FMNH2 [CPD:C01847]
Comment
This enzyme also catalyses the reduction of cob(II)yric acid, cob(II)inamide, cob(II)inamide phosphate, GDP-cob(II)inamide and cob(II)alamin although cob(II)yrinic acid a,c-diamide is thought to be the physiological substrate [1]. Also uses FAD and NADH but not NADPH.
History
EC 1.16.8.1 created 2004
Pathway
Porphyrin and chlorophyll metabolism
Metabolic pathways
Orthology
K13786  
cob(II)yrinic acid a,c-diamide reductase
Genes
MLO: 
MCI: 
MOP: 
MAM: 
MES: 
HOE: 
AAK: 
SME: 
SMK: 
SMQ: 
SMX: 
SMI: 
SMEG: 
SMEL: 
SMER: 
SMD: 
RHI: 
SFH: 
SFD: 
EAD: 
ARA: 
AVI: 
RET: 
REC: 
REL: 
REI: 
REP: 
RLT: 
RLG: 
RLB: 
RLU: 
RTR: 
RHL: 
RGA: 
NGL: 
NGG: 
SHZ: 
BME: 
BMEL: 
BMI: 
BMZ: 
BMG: 
BMW: 
BMEE: 
BAA: 
BABO: 
BABR: 
BABT: 
BABB: 
BABU: 
BABS: 
BABC: 
BMS: 
BSI: 
BSF: 
BSUI: 
BSUP: 
BSUV: 
BSUC: 
BMT: 
BSZ: 
BSV: 
BSW: 
BSG: 
BOV: 
BCS: 
BSK: 
BOL: 
BCAR: 
BCAS: 
BMR: 
BPP: 
BPV: 
BCET: 
BCEE: 
BVL: 
OAN: 
OAH: 
OPS: 
BJP: 
BRC: 
BHE: 
BH09670(nmoB)
BHN: 
BHS: 
BQU: 
BQ07430(nmoB)
BQR: 
BBK: 
BTR: 
BT_1346(nmoB)
BTX: 
BGR: 
Bgr_11940(nmoB)
BCD: 
BVN: 
BANC: 
MEY: 
MAAD: 
AUA: 
TAA: 
 » show all
Taxonomy
Reference
1  [PMID:1429467]
  Authors
Blanche F, Maton L, Debussche L, Thibaut D.
  Title
Purification and characterization of Cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans.
  Journal
J. Bacteriol. 174 (1992) 7452-4.
Reference
2  [PMID:12195810]
  Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
  Title
The biosynthesis of adenosylcobalamin (vitamin B12).
  Journal
Nat. Prod. Rep. 19 (2002) 390-412.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
145539-93-1

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