KEGG   ENZYME: 1.17.3.3Help
Entry
EC 1.17.3.3                 Enzyme                                 

Name
6-hydroxynicotinate dehydrogenase;
6-hydroxynicotinic acid hydroxylase;
6-hydroxynicotinic acid dehydrogenase;
6-hydroxynicotinate hydroxylase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With oxygen as acceptor
BRITE hierarchy
Sysname
6-hydroxynicotinate:O2 oxidoreductase
Reaction(IUBMB)
6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2 [RN:R07221]
Reaction(KEGG)
Substrate
6-hydroxynicotinate [CPD:C01020];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
2,6-dihydroxynicotinate [CPD:C15523];
H2O2 [CPD:C00027]
Comment
Contains [2Fe-2S] iron-sulfur centres, FAD and molybdenum. It also has a catalytically essential, labile selenium that can be removed by reaction with cyanide. In Bacillus niacini, this enzyme is required for growth on nicotinic acid.
History
EC 1.17.3.3 created 2004
Pathway
Nicotinate and nicotinamide metabolism
Reference
1
  Authors
Nagel, M. and Andreesen, J.R.
  Title
Molybdenum-dependent degradation of nicotinic acid by Bacillus sp. DSM 2923.
  Journal
FEMS Microbiol. Lett. 59 (1989) 147-152.
Reference
2
  Authors
Nagel, M. and Andreesen, J.R.
  Title
Purification and characterization of the molybdoenzymes nicotinate dehydrogenase and 6-hydroxynicotinate dehydrogenase from Bacillus niacini.
  Journal
Arch. Microbiol. 154 (1990) 605-613.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
122191-32-6

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