KEGG   ENZYME: 1.17.4.5Help
Entry
EC 1.17.4.5                 Enzyme                                 

Name
vitamin-K-epoxide reductase (warfarin-insensitive)
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With a disulfide as acceptor
BRITE hierarchy
Sysname
3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase
Reaction(IUBMB)
3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol [RN:R03512]
Reaction(KEGG)
R03512;
(other) R05830
Show
Substrate
3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone [CPD:C02785];
oxidized dithiothreitol [CPD:C01119]
Product
2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone;
1,4-dithiothreitol [CPD:C00265]
Comment
Vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide. Not inhibited by warfarin [cf. EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)].
History
EC 1.17.4.5 created 1989 as EC 1.1.4.2, transferred 2014 to EC 1.17.4.5
Reference
1  [PMID:3857611]
  Authors
Mukharji I, Silverman RB.
  Title
Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 2713-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
97089-80-0

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