KEGG   ENZYME: 1.17.5.1Help
Entry
EC 1.17.5.1                 Enzyme                                 

Name
phenylacetyl-CoA dehydrogenase;
phenylacetyl-CoA:acceptor oxidoreductase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
phenylacetyl-CoA:quinone oxidoreductase
Reaction(IUBMB)
phenylacetyl-CoA + H2O + 2 quinone = phenylglyoxylyl-CoA + 2 quinol [RN:R07222]
Reaction(KEGG)
Substrate
phenylacetyl-CoA [CPD:C00582];
H2O [CPD:C00001];
quinone [CPD:C00472]
Product
phenylglyoxylyl-CoA [CPD:C15524];
quinol [CPD:C00530]
Comment
The enzyme from Thauera aromatica is a membrane-bound molybdenum---iron---sulfur protein. The enzyme is specific for phenylacetyl-CoA as substrate. Phenylacetate, acetyl-CoA, benzoyl-CoA, propanoyl-CoA, crotonyl-CoA, succinyl-CoA and 3-hydroxybenzoyl-CoA cannot act as substrates. The oxygen atom introduced into the product, phenylglyoxylyl-CoA, is derived from water and not molecular oxygen. Duroquinone, menaquinone and 2,6-dichlorophenolindophenol (DCPIP) can act as acceptor, but the likely physiological acceptor is ubiquinone [1]. A second enzyme, EC 3.1.2.25, phenylacetyl-CoA hydrolase, converts the phenylglyoxylyl-CoA formed into phenylglyoxylate.
History
EC 1.17.5.1 created 2004
Pathway
Phenylalanine metabolism
Orthology
K18361  
phenylacetyl-CoA:acceptor oxidoreductase
Genes
EBA: 
ebA5393(padB)
AZO: 
azo1946(padB)
AZA: 
AZKH_2904(padB)
TMZ: 
RPD: 
MAG: 
Taxonomy
Reference
1  [PMID:10336636]
  Authors
Rhee SK, Fuchs G.
  Title
Phenylacetyl-CoA:acceptor oxidoreductase, a membrane-bound molybdenum-iron-sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica.
  Journal
Eur. J. Biochem. 262 (1999) 507-15.
Reference
2  [PMID:9575237]
  Authors
Schneider S, Fuchs G.
  Title
Phenylacetyl-CoA:acceptor oxidoreductase, a new alpha-oxidizing enzyme that produces phenylglyoxylate. Assay, membrane localization, and differential production in Thauera aromatica.
  Journal
Arch. Microbiol. 169 (1998) 509-16.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
210756-43-7

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