KEGG   ENZYME: 1.17.5.2Help
Entry
EC 1.17.5.2                 Enzyme                                 

Name
caffeine dehydrogenase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
caffeine:ubiquinone oxidoreductase
Reaction(IUBMB)
caffeine + ubiquinone + H2O = 1,3,7-trimethylurate + ubiquinol [RN:R07980]
Reaction(KEGG)
Substrate
caffeine [CPD:C07481];
ubiquinone [CPD:C00399];
H2O [CPD:C00001]
Product
1,3,7-trimethylurate [CPD:C16361];
ubiquinol [CPD:C00390]
Comment
This enzyme, characterized from the soil bacterium Pseudomonas sp. CBB1, catalyses the incorporation of an oxygen atom originating from a water molecule into position C-8 of caffeine. The enzyme utilizes short-tail ubiquinones as the preferred electron acceptor.
History
EC 1.17.5.2 created 2010
Pathway
Caffeine metabolism
Microbial metabolism in diverse environments
Orthology
K21673  
caffeine dehydrogenase subunit alpha
K21674  
caffeine dehydrogenase subunit beta
K21675  
caffeine dehydrogenase subunit gamma
Reference
1  [PMID:17981969]
  Authors
Yu CL, Kale Y, Gopishetty S, Louie TM, Subramanian M
  Title
A novel caffeine dehydrogenase in Pseudomonas sp. strain CBB1 oxidizes caffeine to trimethyluric acid.
  Journal
J. Bacteriol. 190 (2008) 772-6.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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