KEGG   ENZYME: 1.17.5.2Help
Entry
EC 1.17.5.2                 Enzyme                                 

Name
caffeine dehydrogenase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
caffeine:ubiquinone oxidoreductase
Reaction(IUBMB)
caffeine + ubiquinone + H2O = 1,3,7-trimethylurate + ubiquinol [RN:R07980]
Reaction(KEGG)
Substrate
caffeine [CPD:C07481];
ubiquinone [CPD:C00399];
H2O [CPD:C00001]
Product
1,3,7-trimethylurate [CPD:C16361];
ubiquinol [CPD:C00390]
Comment
This enzyme, characterized from the soil bacterium Pseudomonas sp. CBB1, catalyses the incorporation of an oxygen atom originating from a water molecule into position C-8 of caffeine. The enzyme utilizes short-tail ubiquinones as the preferred electron acceptor.
History
EC 1.17.5.2 created 2010
Reference
1  [PMID:17981969]
  Authors
Yu CL, Kale Y, Gopishetty S, Louie TM, Subramanian M
  Title
A novel caffeine dehydrogenase in Pseudomonas sp. strain CBB1 oxidizes caffeine to trimethyluric acid.
  Journal
J. Bacteriol. 190 (2008) 772-6.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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