KEGG   ENZYME: 1.17.99.2Help
Entry
EC 1.17.99.2                Enzyme                                 

Name
ethylbenzene hydroxylase;
ethylbenzene dehydrogenase;
ethylbenzene:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With other acceptors
BRITE hierarchy
Sysname
ethylbenzene:acceptor oxidoreductase
Reaction(IUBMB)
ethylbenzene + H2O + acceptor = (S)-1-phenylethanol + reduced acceptor [RN:R05745]
Reaction(KEGG)
Substrate
ethylbenzene [CPD:C07111];
H2O [CPD:C00001];
acceptor [CPD:C00028]
Product
(S)-1-phenylethanol [CPD:C11348];
reduced acceptor [CPD:C00030]
Comment
Involved in the anaerobic catabolism of ethylbenzene by denitrifying bacteria. Ethylbenzene is the preferred substrate; the enzyme from some strains oxidizes propylbenzene, 1-ethyl-4-fluorobenzene, 3-methylpent-2-ene and ethylidenecyclohexane. Toluene is not oxidized. p-Benzoquinone or ferrocenium can act as electron acceptor. Contains molybdopterin, [4Fe-4S] clusters and heme b.
Pathway
Ethylbenzene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K10700  
ethylbenzene hydroxylase subunit alpha
Genes
EBA: 
c1A65(ebdA)
Taxonomy
Reference
1  [PMID:11294876]
  Authors
Kniemeyer O, Heider J.
  Title
Ethylbenzene dehydrogenase, a novel hydrocarbon-oxidizing molybdenum/iron-sulfur/heme enzyme.
  Journal
J. Biol. Chem. 276 (2001) 21381-6.
  Organism
Azoarcus sp.
Reference
2  [PMID:11443088]
  Authors
Johnson HA, Pelletier DA, Spormann AM.
  Title
Isolation and characterization of anaerobic ethylbenzene dehydrogenase, a novel Mo-Fe-S enzyme.
  Journal
J. Bacteriol. 183 (2001) 4536-42.
  Organism
Azoarcus sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
372947-56-3

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