KEGG   ENZYME: 1.18.1.5Help
Entry
EC 1.18.1.5                 Enzyme                                 

Name
putidaredoxin---NAD+ reductase;
putidaredoxin reductase;
camA (gene name)
Class
Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
putidaredoxin:NAD+ oxidoreductase
Reaction(IUBMB)
reduced putidaredoxin + NAD+ = oxidized putidaredoxin + NADH + H+ [RN:R10048]
Reaction(KEGG)
Substrate
reduced putidaredoxin;
NAD+ [CPD:C00003]
Product
oxidized putidaredoxin [CPD:C03302];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Requires FAD. The enzyme from Pseudomonas putida reduces putidaredoxin. It contains a [2Fe-2S] cluster. Involved in the camphor monooxygenase system (see EC 1.14.15.1, camphor 5-monooxygenase).
History
EC 1.18.1.5 created 2012
Reference
1  [PMID:6401738]
  Authors
Roome PW Jr, Philley JC, Peterson JA
  Title
Purification and properties of putidaredoxin reductase.
  Journal
J. Biol. Chem. 258 (1983) 2593-8.
Reference
2  [PMID:2613690]
  Authors
Koga H, Yamaguchi E, Matsunaga K, Aramaki H, Horiuchi T
  Title
Cloning and nucleotide sequences of NADH-putidaredoxin reductase gene (camA) and  putidaredoxin gene (camB) involved in cytochrome P-450cam hydroxylase of Pseudomonas putida.
  Journal
J. Biochem. 106 (1989) 831-6.
Reference
3  [PMID:2180940]
  Authors
Peterson JA, Lorence MC, Amarneh B
  Title
Putidaredoxin reductase and putidaredoxin. Cloning, sequence determination, and heterologous expression of the proteins.
  Journal
J. Biol. Chem. 265 (1990) 6066-73.
  Sequence
Reference
4  [PMID:12011076]
  Authors
Sevrioukova IF, Poulos TL
  Title
Putidaredoxin reductase, a new function for an old protein.
  Journal
J. Biol. Chem. 277 (2002) 25831-9.
  Sequence
Reference
5  [PMID:14529624]
  Authors
Sevrioukova IF, Garcia C, Li H, Bhaskar B, Poulos TL
  Title
Crystal structure of putidaredoxin, the [2Fe-2S] component of the P450cam monooxygenase system from Pseudomonas putida.
  Journal
J. Mol. Biol. 333 (2003) 377-92.
Reference
6  [PMID:15095867]
  Authors
Sevrioukova IF, Li H, Poulos TL
  Title
Crystal structure of putidaredoxin reductase from Pseudomonas putida, the final structural component of the cytochrome P450cam monooxygenase.
  Journal
J. Mol. Biol. 336 (2004) 889-902.
  Sequence
Reference
7  [PMID:15103126]
  Authors
Smith N, Mayhew M, Holden MJ, Kelly H, Robinson H, Heroux A, Vilker VL, Gallagher DT
  Title
Structure of C73G putidaredoxin from Pseudomonas putida.
  Journal
Acta. Crystallogr. D. Biol. Crystallogr. 60 (2004) 816-22.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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