| Entry |
|
|---|
| Name |
aminomuconate-semialdehyde dehydrogenase;
2-aminomuconate semialdehyde dehydrogenase;
2-hydroxymuconic acid semialdehyde dehydrogenase;
2-hydroxymuconate semialdehyde dehydrogenase;
alpha-aminomuconic epsilon-semialdehyde dehydrogenase;
alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase;
2-hydroxymuconic semialdehyde dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase |
|---|
| Reaction(IUBMB) |
2-aminomuconate 6-semialdehyde + NAD+ + H2O = 2-aminomuconate + NADH
+ 2 H+ [RN:R03889] |
|---|
| Reaction(KEGG) |
R03889;
(other) R02762 R05353
 |
|---|
| Substrate |
2-aminomuconate 6-semialdehyde [CPD:C03824];
NAD+ [CPD:C00003];
H2O [CPD:C00001] |
|---|
| Product |
2-aminomuconate [CPD:C02220];
NADH [CPD:C00004];
H+ [CPD:C00080] |
|---|
| Comment |
Also acts on 2-hydroxymuconate semialdehyde. |
|---|
| Pathway |
PATH: ec00362 Benzoate degradation via hydroxylation
PATH: ec00380 Tryptophan metabolism
PATH: ec00622 Toluene and xylene degradation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K10217 aminomuconate-semialdehyde dehydrogenase |
|---|
| Genes |
REH: H16_B0547
RHA: RHA1_ro03868
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:14275130]
ICHIYAMA A, NAKAMURA S, KAWAI H, HONJO T, NISHIZUKA Y, HAYAISHI O,
SENOH S.
STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN
MAMMALIAN TISSUES. II. ENZYMIC FORMATION OF ALPHA-AMINOMUCONIC ACID
FROM 3-HYDROXYANTHRANILIC ACID.
J. Biol. Chem. 240 (1965) 740-9.
Felis catus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.2.1.32
IUBMB Enzyme Nomenclature: 1.2.1.32
ExPASy - ENZYME nomenclature database: 1.2.1.32
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.32
BRENDA, the Enzyme Database: 1.2.1.32
CAS: 37250-95-6 |
|---|
