KEGG   ENZYME: 1.2.1.43Help
Entry
EC 1.2.1.43                 Enzyme                                 
Name
formate dehydrogenase (NADP+);
NADP+-dependent formate dehydrogenase;
formate dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
formate:NADP+ oxidoreductase
Reaction(IUBMB)
formate + NADP+ = CO2 + NADPH [RN:R00134]
Reaction(KEGG)
Substrate
formate [CPD:C00058];
NADP+ [CPD:C00006]
Product
CO2 [CPD:C00011];
NADPH [CPD:C00005]
Comment
A tungsten-selenium-iron protein.
Pathway
Methane metabolism
Carbon fixation pathways in prokaryotes
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K05299  
formate dehydrogenase alpha subunit
K15022  
formate dehydrogenase beta subunit
Genes
LHK: 
WSU: 
WS0477(FDHB)
TDN: 
SUA: 
SKU: 
SULR: 
NSA: 
NIS: 
SUN: 
GSU: 
GSU0510(sfrB)
GSK: 
KN400_0499(sfrB)
GME: 
Gmet_3023(sfrB)
GUR: 
Gura_3640
GLO: 
Glov_0660
GBM: 
Gbem_0659(sfrB)
GEO: 
Geob_1607
GEM: 
GM21_0672
GEB: 
GM18_3696
PCA: 
Pcar_2503(sfrB)
DVU: 
DVU1772
DVL: 
Dvul_1383
DVG: 
Deval_1526
DDS: 
Ddes_1543
DAT: 
HRM2_26590(gltD1)
DTI: 
Desti_2930
DBR: 
Deba_0487
RPA: 
RPA0135
RPE: 
RPE_3861
RPT: 
Rpal_0138
RPX: 
Rpdx1_0129
AMT: 
Amet_4098
DSY: 
DSY3968(fdhF)
DHD: 
Dhaf_1398
DAE: 
Dtox_3503 Dtox_3507
DAU: 
Daud_0104
TJR: 
TherJR_0670 TherJR_0942
SGY: 
Sgly_2685
HMO: 
HM1_1745(fdhA)
CHY: 
CHY_0733(fdhA)
MTA: 
Moth_2312(fdhA) Moth_2314
ADG: 
Adeg_0156
TOC: 
Toce_0785
NTH: 
Nther_0100
AAR: 
Acear_2299
DDF: 
DEFDS_1613
DAP: 
Dacet_2494
CNI: 
Calni_1870
FSI: 
Flexsi_0433
 » show all
Taxonomy
Reference
1  [PMID:4154039]
  Authors
Andreesen JR, Ljungdahl LG.
  Title
Nicotinamide adenine dinucleotide phosphate-dependent formate dehydrogenase from Clostridium thermoaceticum: purification and properties.
  Journal
J. Bacteriol. 120 (1974) 6-14.
  Organism
Moorella thermoacetica [GN:mta]
Reference
2  [PMID:6822536]
  Authors
Yamamoto I, Saiki T, Liu SM, Ljungdahl LG.
  Title
Purification and properties of NADP-dependent formate dehydrogenase from Clostridium thermoaceticum, a tungsten-selenium-iron protein.
  Journal
J. Biol. Chem. 258 (1983) 1826-32.
  Organism
Moorella thermoacetica [GN:mta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
51377-43-6
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