KEGG   ENZYME: 1.2.1.49Help
Entry
EC 1.2.1.49                 Enzyme                                 

Name
2-oxoaldehyde dehydrogenase (NADP+);
alpha-ketoaldehyde dehydrogenase;
methylglyoxal dehydrogenase;
NADP+-linked alpha-ketoaldehyde dehydrogenase;
2-ketoaldehyde dehydrogenase;
NADP+-dependent alpha-ketoaldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-oxoaldehyde:NADP+ 2-oxidoreductase
Reaction(IUBMB)
a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo carboxylate + NADPH + H+ [RN:R01338]
Reaction(KEGG)
R01338 > R00205;
(other) R02260
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Substrate
2-oxoaldehyde [CPD:C00538];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
2-oxo carboxylate [CPD:C00161];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Not identical with EC 1.2.1.23 2-oxoaldehyde dehydrogenase (NAD+).
History
EC 1.2.1.49 created 1986
Pathway
Pyruvate metabolism
Reference
1  [PMID:7107626]
  Authors
Ray M, Ray S.
  Title
On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase.
  Journal
J. Biol. Chem. 257 (1982) 10571-4.
Reference
2  [PMID:7107625]
  Authors
Ray S, Ray M.
  Title
Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate.
  Journal
J. Biol. Chem. 257 (1982) 10566-70.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
83588-97-0 97162-76-0

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