KEGG   ENZYME: 1.2.1.50Help
Entry
EC 1.2.1.50                 Enzyme                                 

Name
long-chain acyl-protein thioester reductase;
luxC (gene name);
acyl-CoA reductase;
acyl coenzyme A reductase;
long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming);
long-chain-fatty-acyl-CoA reductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
long-chain-aldehyde:NADP+ oxidoreductase (protein thioester-forming)
Reaction(IUBMB)
a long-chain aldehyde + [protein]-L-cysteine + NADP+ = a [protein]-S-(long-chain fatty acyl)-L-cysteine + NADPH + H+ [RN:R02620]
Reaction(KEGG)
R02620;
(other) R10549
Show
Substrate
long-chain aldehyde [CPD:C00609];
[protein]-L-cysteine;
NADP+ [CPD:C00006]
Product
[protein]-S-(long-chain fatty acyl)-L-cysteine;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Together with a transferase component (EC 3.1.2.2 and EC 3.1.2.14) and a synthetase component (EC 6.2.1.19), this enzyme forms a multienzyme fatty acid reductase complex that produces the long-chain aldehyde substrate of the bacterial luciferase enzyme (EC 1.14.14.3). The enzyme is acylated by receiving an acyl group from EC 6.2.1.19, and catalyses the reduction of the acyl group, releasing the aldehyde product. The enzyme is also able to accept the acyl group from a long-chain acyl-CoA.
History
EC 1.2.1.50 created 1986, modified 2016
Pathway
Cutin, suberine and wax biosynthesis
Biosynthesis of secondary metabolites
Orthology
K03400  
long-chain-fatty-acyl-CoA reductase
Genes
PLU: 
plu2079(luxC)
PAY: 
PAU_02514(luxC)
PTT: 
VHA: 
VCA: 
VFI: 
VF_A0923(luxC)
VFM: 
VSA: 
SWD: 
Taxonomy
Reference
1  [PMID:7085612]
  Authors
Riendeau D, Rodriguez A, Meighen E.
  Title
Resolution of the fatty acid reductase from Photobacterium phosphoreum into acyl protein synthetase and acyl-CoA reductase activities. Evidence for an enzyme complex.
  Journal
J. Biol. Chem. 257 (1982) 6908-15.
Reference
2
  Authors
Wall, L. and Meighen, E.A.
  Title
Subunit structure of the fatty-acid reductase complex from Photobacterium phosphoreum.
  Journal
Biochemistry 25 (1986) 4315-4321.
Reference
3  [PMID:8447834]
  Authors
Lin JW, Chao YF, Weng SF
  Title
Nucleotide sequence of the luxC gene encoding fatty acid reductase of the lux operon from Photobacterium leiognathi.
  Journal
Biochem. Biophys. Res. Commun. 191 (1993) 314-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
50936-56-6

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