KEGG   ENZYME: 1.2.1.51Help
Entry
EC 1.2.1.51                 Enzyme                                 

Name
pyruvate dehydrogenase (NADP+);
pyruvate dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)
Reaction(IUBMB)
pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH [RN:R00210]
Reaction(KEGG)
Substrate
pyruvate [CPD:C00022];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
acetyl-CoA [CPD:C00024];
CO2 [CPD:C00011];
NADPH [CPD:C00005]
Comment
The Euglena enzyme can also use FAD or methyl viologen as acceptor, more slowly. The enzyme is inhibited by oxygen.
History
EC 1.2.1.51 created 1989
Reference
1  [PMID:6438078]
  Authors
Inui H, Miyatake K, Nakano Y, Kitaoka S.
  Title
Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis.
  Journal
J. Biochem. (Tokyo). 96 (1984) 931-4.
Reference
2  [PMID:3110154]
  Authors
Inui H, Ono K, Miyatake K, Nakano Y, Kitaoka S.
  Title
Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis.
  Journal
J. Biol. Chem. 262 (1987) 9130-5.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
93389-35-6

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