KEGG   ENZYME: 1.2.1.51Help
Entry
EC 1.2.1.51                 Enzyme                                 

Name
pyruvate dehydrogenase (NADP+);
pyruvate dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)
Reaction(IUBMB)
pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH [RN:R00210]
Reaction(KEGG)
Substrate
pyruvate [CPD:C00022];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
acetyl-CoA [CPD:C00024];
CO2 [CPD:C00011];
NADPH [CPD:C00005]
Comment
The Euglena enzyme can also use FAD or methyl viologen as acceptor, more slowly. The enzyme is inhibited by oxygen.
History
EC 1.2.1.51 created 1989
Orthology
K21682  
pyruvate dehydrogenase (NADP+) / aquacobalamin reductase (NADPH)
Genes
CPV: 
SMIN: 
v1.2.029520.t1(symbB.v1.2.029520.t1) v1.2.029521.t1(symbB.v1.2.029521.t1)
GTT: 
Taxonomy
Reference
1  [PMID:6438078]
  Authors
Inui H, Miyatake K, Nakano Y, Kitaoka S.
  Title
Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis.
  Journal
J. Biochem. (Tokyo). 96 (1984) 931-4.
Reference
2  [PMID:3110154]
  Authors
Inui H, Ono K, Miyatake K, Nakano Y, Kitaoka S.
  Title
Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis.
  Journal
J. Biol. Chem. 262 (1987) 9130-5.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
93389-35-6

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