KEGG   ENZYME: 1.2.1.52Help
Entry
EC 1.2.1.52                 Enzyme                                 

Name
oxoglutarate dehydrogenase (NADP+);
oxoglutarate dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)
Reaction(IUBMB)
2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH [RN:R00265]
Reaction(KEGG)
Substrate
2-oxoglutarate [CPD:C00026];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
succinyl-CoA [CPD:C00091];
CO2 [CPD:C00011];
NADPH [CPD:C00005]
Comment
The Euglena enzyme can also use NAD+ as acceptor, but more slowly.
History
EC 1.2.1.52 created 1989
Reference
1  [PMID:6438078]
  Authors
Inui H, Miyatake K, Nakano Y, Kitaoka S.
  Title
Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis.
  Journal
J. Biochem. (Tokyo). 96 (1984) 931-4.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
126469-85-0

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