KEGG   ENZYME: 1.2.1.63Help
Entry
EC 1.2.1.63                 Enzyme                                 

Name
6-oxohexanoate dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
6-oxohexanoate:NADP+ oxidoreductase
Reaction(IUBMB)
6-oxohexanoate + NADP+ + H2O = adipate + NADPH + 2 H+ [RN:R05099]
Reaction(KEGG)
Substrate
6-oxohexanoate [CPD:C06102];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
adipate [CPD:C06104];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Last step in the cyclohexanol degradation pathway in Acinetobacter sp.
History
EC 1.2.1.63 created 2000
Pathway
Caprolactam degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K19962  
6-oxohexanoate dehydrogenase
Genes
PPJ: 
Taxonomy
Reference
1  [PMID:856571]
  Authors
Davey JF, Trudgill PW.
  Title
The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species.
  Journal
Eur. J. Biochem. 74 (1977) 115-27.
Reference
2  [PMID:1261]
  Authors
Donoghue NA, Trudgill PW.
  Title
The metabolism of cyclohexanol by Acinetobacter NCIB 9871.
  Journal
Eur. J. Biochem. 60 (1975) 1-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
62628-29-9

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