KEGG   ENZYME: 1.2.1.64Help
Entry
EC 1.2.1.64                 Enzyme                                 

Name
4-hydroxybenzaldehyde dehydrogenase (NAD+);
p-hydroxybenzaldehyde dehydrogenase (ambiguous);
4-hydroxybenzaldehyde dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-hydroxybenzaldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + 2 H+ [RN:R01293]
Reaction(KEGG)
R01293;
(other) R07667
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Substrate
4-hydroxybenzaldehyde [CPD:C00633];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
4-hydroxybenzoate [CPD:C00156];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The bacterial enzyme (characterized from an unidentified denitrifying bacterium) is involved in an anaerobic toluene degradation pathway. The plant enzyme is involved in formation of 4-hydroxybenzoate, a cell wall-bound phenolic acid that plays a major role in plant defense against pathogens. cf. EC 1.2.1.96, 4-hydroxybenzaldehyde dehydrogenase (NADP+).
History
EC 1.2.1.64 created 2000, modified 2015
Pathway
Toluene degradation
Aminobenzoate degradation
Microbial metabolism in diverse environments
Reference
1  [PMID:2722739]
  Authors
Bossert ID, Whited G, Gibson DT, Young LY.
  Title
Anaerobic oxidation of p-cresol mediated by a partially purified methylhydroxylase from a denitrifying bacterium.
  Journal
J. Bacteriol. 171 (1989) 2956-62.
Reference
2  [PMID:17658659]
  Authors
Sircar D, Mitra A
  Title
Evidence for p-hydroxybenzoate formation involving enzymatic phenylpropanoid side-chain cleavage in hairy roots of Daucus carota.
  Journal
J. Plant. Physiol. 165 (2008) 407-14.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
61229-72-9

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