KEGG   ENZYME: 1.2.1.73Help
Entry
EC 1.2.1.73                 Enzyme                                 

Name
sulfoacetaldehyde dehydrogenase;
SafD
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-sulfoacetaldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
2-sulfoacetaldehyde + H2O + NAD+ = sulfoacetate + NADH + 2 H+ [RN:R06980]
Reaction(KEGG)
Substrate
2-sulfoacetaldehyde [CPD:C00593];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
sulfoacetate [CPD:C14179];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This reaction is part of a bacterial pathway that can utilize the amino group of taurine as a sole source of nitrogen for growth. At physiological concentrations, NAD+ cannot be replaced by NADP+. The enzyme is specific for sulfoacetaldehyde, as formaldehyde, acetaldehyde, betaine aldehyde, propanal, glyceraldehyde, phosphonoacetaldehyde, glyoxylate, glycolaldehyde and 2-oxobutyrate are not substrates.
History
EC 1.2.1.73 created 2008
Pathway
Taurine and hypotaurine metabolism
Orthology
K19699  
sulfoacetaldehyde dehydrogenase
Reference
1  [PMID:18506422]
  Authors
Krejcik Z, Denger K, Weinitschke S, Hollemeyer K, Paces V, Cook AM, Smits TH.
  Title
Sulfoacetate released during the assimilation of taurine-nitrogen by Neptuniibacter caesariensis: purification of sulfoacetaldehyde dehydrogenase.
  Journal
Arch. Microbiol. 190 (2008) 159-68.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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