KEGG   ENZYME: 1.2.1.78Help
Entry
EC 1.2.1.78                 Enzyme                                 

Name
2-formylbenzoate dehydrogenase;
2-carboxybenzaldehyde dehydrogenase;
2CBAL dehydrogenase;
PhdK
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-formylbenzoate:NAD+ oxidoreductase
Reaction(IUBMB)
2-formylbenzoate + NAD+ + H2O = o-phthalic acid + NADH + H+ [RN:R05643]
Reaction(KEGG)
Substrate
2-formylbenzoate [CPD:C03057];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
o-phthalic acid [CPD:C01606];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme is involved in phenanthrene degradation.
History
EC 1.2.1.78 created 2010
Pathway
Polycyclic aromatic hydrocarbon degradation
Microbial metabolism in diverse environments
Orthology
K18275  
2-formylbenzoate dehydrogenase
Genes
MVA: 
MGI: 
MSP: 
MMC: 
MKM: 
MJL: 
MRH: 
Taxonomy
Reference
1  [PMID:9335300]
  Authors
Iwabuchi T, Harayama S
  Title
Biochemical and genetic characterization of 2-carboxybenzaldehyde dehydrogenase,  an enzyme involved in phenanthrene degradation by Nocardioides sp. strain KP7.
  Journal
J. Bacteriol. 179 (1997) 6488-94.
Reference
2
  Authors
Kiyohara, H., Nagao, K. and Yano, K.
  Title
Isolation and some properties of NAD-linked 2-carboxybenzaldehyde dehydrogenase in Alcaligenes faecalis AFK 2 grown on phenanthrene.
  Journal
J. Gen. Appl. Microbiol. 27 (1981) 443-455.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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