KEGG   ENZYME: 1.2.1.81Help
Entry
EC 1.2.1.81                 Enzyme                                 

Name
sulfoacetaldehyde dehydrogenase (acylating);
SauS
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-sulfoacetaldehyde:NADP+ oxidoreductase (CoA-acetylating)
Reaction(IUBMB)
2-sulfoacetaldehyde + CoA + NADP+ = sulfoacetyl-CoA + NADPH + H+ [RN:R09557]
Reaction(KEGG)
Substrate
2-sulfoacetaldehyde [CPD:C00593];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
sulfoacetyl-CoA [CPD:C19685];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is involved in degradation of sulfoacetate. In this pathway the reaction is catalysed in the reverse direction. The enzyme is specific for sulfoacetaldehyde and NADP+.
History
EC 1.2.1.81 created 2011
Orthology
K15515  sulfoacetaldehyde dehydrogenase
Genes
BGJ: AWC36_05910
SPOI: IMCC21906_02808
ZAL: AZF00_04515
OSG: BST96_16725
HJA: BST95_16535
GAI: IMCC3135_23095(sauS)
SVA: SVA_0813
TSN: W908_04745
RPJ: N234_15545
REU: Reut_A0867
REH: H16_A2747(h16_A2747)
CNC: CNE_1c26440(sucD2)
BXE: Bxe_B0701
BXB: DR64_6032
BPH: Bphy_6218
BFN: OI25_4376
PPNO: DA70_10965
PPNM: LV28_20085
PSPU: NA29_22760
VEI: Veis_4280
VPD: VAPA_1c39430(sucD1)
AZA: AZKH_2613(gabD)
AOL: S58_09680
RPE: RPE_3204
OCA: OCAR_6738
OCG: OCA5_c13340(sucD1)
OCO: OCA4_c13340(sucD1)
MDI: METDI0777
MCH: Mchl_4208
META: Y590_17370
RVA: Rvan_3429
FIL: BN1229_v1_2532(sauS)
FIY: BN1229_v1_3384(sauS)
JAN: Jann_1566
RDE: RD1_2918(adhE)
PDE: Pden_1013
PTP: RCA23_c28350(sucD2)
RMM: ROSMUCSMR3_02418(sauS)
BACO: OXB_2779
DSY: DSY0244
DHD: Dhaf_0190
AIN: Acin_0046(adhE)
SALB: XNR_3458
SUS: Acid_3101
 » show all
Taxonomy
Reference
1  [PMID:20693281]
  Authors
Weinitschke S, Hollemeyer K, Kusian B, Bowien B, Smits TH, Cook AM
  Title
Sulfoacetate is degraded via a novel pathway involving sulfoacetyl-CoA and sulfoacetaldehyde in Cupriavidus necator H16.
  Journal
J. Biol. Chem. 285 (2010) 35249-54.
  Sequence
[reh:H16_A2747]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.81
IUBMB Enzyme Nomenclature: 1.2.1.81
ExPASy - ENZYME nomenclature database: 1.2.1.81
BRENDA, the Enzyme Database: 1.2.1.81

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