KEGG   ENZYME: 1.2.1.81Help
Entry
EC 1.2.1.81                 Enzyme                                 

Name
sulfoacetaldehyde dehydrogenase (acylating);
SauS
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-sulfoacetaldehyde:NADP+ oxidoreductase (CoA-acetylating)
Reaction(IUBMB)
2-sulfoacetaldehyde + CoA + NADP+ = sulfoacetyl-CoA + NADPH + H+ [RN:R09557]
Reaction(KEGG)
Substrate
2-sulfoacetaldehyde [CPD:C00593];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
sulfoacetyl-CoA [CPD:C19685];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is involved in degradation of sulfoacetate. In this pathway the reaction is catalysed in the reverse direction. The enzyme is specific for sulfoacetaldehyde and NADP+.
History
EC 1.2.1.81 created 2011
Orthology
K15515  
sulfoacetaldehyde dehydrogenase
Genes
SPOI: 
ZAL: 
TSN: 
RPJ: 
REU: 
REH: 
H16_A2747(h16_A2747)
CNC: 
BYI: 
BUO: 
BUE: 
BXE: 
BXB: 
BPH: 
BPY: 
BFN: 
PPK: 
PPNO: 
PPNM: 
PRB: 
PSPU: 
PTX: 
PFG: 
AKA: 
VEI: 
VAP: 
VPE: 
VPD: 
AZA: 
AZKH_2613(gabD)
DFI: 
AOL: 
RPE: 
OCA: 
OCG: 
OCO: 
MDI: 
MCH: 
META: 
RVA: 
FIL: 
FIY: 
JAN: 
RDE: 
RD1_2918(adhE)
RLI: 
PDE: 
PGA: 
LMD: 
PTP: 
CMAR: 
NPP: 
NRE: 
ABS: 
ABQ: 
BACO: 
GFE: 
DSY: 
DHD: 
DRU: 
PFT: 
AIN: 
Acin_0046(adhE)
MSA: 
MRH: 
MCB: 
SALB: 
PPC: 
PHH: 
SFC: 
TRS: 
SUS: 
AMO: 
CPOR: 
 » show all
Taxonomy
Reference
1  [PMID:20693281]
  Authors
Weinitschke S, Hollemeyer K, Kusian B, Bowien B, Smits TH, Cook AM
  Title
Sulfoacetate is degraded via a novel pathway involving sulfoacetyl-CoA and sulfoacetaldehyde in Cupriavidus necator H16.
  Journal
J. Biol. Chem. 285 (2010) 35249-54.
  Sequence
[reh:H16_A2747]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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