KEGG   ENZYME: 1.2.1.83Help
Entry
EC 1.2.1.83                 Enzyme                                 

Name
3-succinoylsemialdehyde-pyridine dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-oxo-4-(pyridin-3-yl)butanal:NADP+ oxidoreductase
Reaction(IUBMB)
4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O = 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+ [RN:R10105]
Reaction(KEGG)
Substrate
4-oxo-4-(pyridin-3-yl)butanal [CPD:C19567];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
4-oxo-4-(pyridin-3-yl)butanoate [CPD:C19569];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6. It participates in the nicotine degradation pathway.
History
EC 1.2.1.83 created 2012
Pathway
Nicotinate and nicotinamide metabolism
Microbial metabolism in diverse environments
Orthology
K19700  
3-succinoylsemialdehyde-pyridine dehydrogenase
Genes
PPT: 
PMON: 
PMOT: 
Taxonomy
Reference
1  [PMID:22267672]
  Authors
Qiu J, Ma Y, Wen Y, Chen L, Wu L, Liu W
  Title
Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine.
  Journal
Appl. Environ. Microbiol. 78 (2012) 2154-60.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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