KEGG   ENZYME: 1.2.1.85Help
Entry
EC 1.2.1.85                 Enzyme                                 

Name
2-hydroxymuconate-6-semialdehyde dehydrogenase;
xylG (gene name);
praB (gene name)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-hydroxymuconate-6-semialdehyde:NAD+ oxidoreductase
Reaction(IUBMB)
2-hydroxymuconate-6-semialdehyde + NAD+ + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+ [RN:R02762]
Reaction(KEGG)
R02762;
(other) R05353
Show
Substrate
2-hydroxymuconate-6-semialdehyde [CPD:C00682];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate;
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This substrate for this enzyme is formed by meta ring cleavage of catechol (EC 1.13.11.2, catechol 2,3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds. Has lower activity with benzaldehyde [1]. Activity with NAD+ is more than 10-fold higher than with NADP+ [3]. cf. EC 1.2.1.32, aminomuconate-semialdehyde dehydrogenase.
History
EC 1.2.1.85 created 2012
Pathway
Benzoate degradation
Xylene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K10217  
aminomuconate-semialdehyde/2-hydroxymuconate-6-semialdehyde dehydrogenase
Genes
SLQ: 
PGE: 
PSD: 
LAB: 
LA76x_2548(aldH8A1)
LCP: 
LC55x_2794(aldH8A1)
LGU: 
LG3211_2666(aldh8a1)
RHD: 
DJI: 
DJA: 
PPSE: 
BN5_3621(xylG)
PPW: 
PPJ: 
PSC: 
PSTU: 
PBM: 
PKC: 
PKB_3261(amnc1) PKB_3609(amnc3)
PALK: 
PSOS: 
AVN: 
AVL: 
AVD: 
ACX: 
SWD: 
MAD: 
HP15_1111(betB) HP15_4032(betB)
MSR: 
LAL: 
CYQ: 
Q91_0507(xylG) Q91_1784(lapC)
CZA: 
BLEP: 
WMA: 
HCS: 
APAC: 
KKO: 
KGE: 
TBN: 
RSO: 
RSp0890(dmpC)
RSM: 
RSE: 
RPI: 
RPF: 
RPJ: 
REU: 
REH: 
H16_B0547(h16_B0547)
CNC: 
RME: 
Rmet_1322(dmpC) Rmet_5206(amnC)
CBW: 
BVI: 
BUR: 
BCJ: 
BCAM2132(nbaE)
BCEN: 
BCEO: 
I35_6014(nbaE)
BMUL: 
BCT: 
BCED: 
BCON: 
BUG: 
BUQ: 
BXE: 
Bxe_A1147(amnC)
BXB: 
BRH: 
BPX: 
BPY: 
BFN: 
PPK: 
PPNO: 
PPNM: 
PRB: 
PPUL: 
PSPU: 
PAPI: 
PVE: 
POX: 
PFG: 
PNR: 
BAV: 
BAV0552(amnC)
BHZ: 
ACR54_00824(amnC_1)
AXY: 
AXO: 
AXN: 
AXS: 
ADT: 
PUT: 
CDN: 
POL: 
AJS: 
VEI: 
VPD: 
CTT: 
ADN: 
ADK: 
MPT: 
JAG: 
LCH: 
AZO: 
azo1852(lapC) azo2435(nahI)
DAR: 
TMZ: 
THU: 
RBU: 
ARC: 
BBAC: 
MXA: 
MFU: 
MSD: 
MYM: 
CCX: 
SUR: 
AGE: 
ARA: 
Arad_7263(betB)
MSL: 
CHEL: 
MAAD: 
NAR: 
NPP: 
NPN: 
SMAG: 
STER: 
SWI: 
SJP: 
SJA_C1-11860(hpaE_xylG)
SYB: 
ERY: 
CNA: 
TMO: 
TMO_b0431(dmpC)
MAGQ: 
BLI: 
BLD: 
BLi03994(dmpC)
BLH: 
BCA: 
BCX: 
BCF: 
BCER: 
BCEF: 
BTL: 
BMYC: 
BPF: 
BMQ: 
BMD: 
BMEG: 
BACI: 
GST: 
BACO: 
BSM: 
BSJ: 
GTN: 
GTNG_3154(nbaE)
GTH: 
GYC: 
GYA: 
GCT: 
GMC: 
GGH: 
GJF: 
LGY: 
LAO: 
FPN: 
BBE: 
PNP: 
ANX: 
AAC: 
AAD: 
TC41_1518(hpaE)
BTS: 
TMR: 
SAY: 
TPY_0646(hpaE)
SAP: 
LPIL: 
MIT: 
MIA: 
MJL: 
MGO: 
NFA: 
NNO: 
RHA: 
RER: 
REY: 
REB: 
ROP: 
REQ: 
REQ_05040(amnC)
RPY: 
RAV: 
GBR: 
SCB: 
SSX: 
SBH: 
MVD: 
ICA: 
KFL: 
TCU: 
SRO: 
FRI: 
ALU: 
PDX: 
STP: 
SAQ: 
MAU: 
MIL: 
VMA: 
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
TTJ: 
TTL: 
TSC: 
THC: 
TOS: 
ABA: 
CTM: 
FLI: 
HSW: 
HYM: 
HYD: 
HYE: 
HYG: 
PKO: 
RUF: 
RTI: 
RUD: 
MTT: 
CAT: 
KDI: 
DOK: 
DDO: 
I597_1376(amnC)
LAN: 
ASL: 
NDO: 
NOM: 
POM: 
WIN: 
FTE: 
OHO: 
BBAU: 
 » show all
Taxonomy
Reference
1  [PMID:7868591]
  Authors
Inoue J, Shaw JP, Rekik M, Harayama S
  Title
Overlapping substrate specificities of benzaldehyde dehydrogenase (the xylC gene  product) and 2-hydroxymuconic semialdehyde dehydrogenase (the xylG gene product)  encoded by TOL plasmid pWW0 of Pseudomonas putida.
  Journal
J. Bacteriol. 177 (1995) 1196-201.
  Sequence
Reference
2  [PMID:17090920]
  Authors
Orii C, Takenaka S, Murakami S, Aoki K
  Title
Metabolism of 4-amino-3-hydroxybenzoic acid by Bordetella sp. strain 10d: A different modified meta-cleavage pathway for 2-aminophenols.
  Journal
Biosci. Biotechnol. Biochem. 70 (2006) 2653-61.
Reference
3  [PMID:19717587]
  Authors
Kasai D, Fujinami T, Abe T, Mase K, Katayama Y, Fukuda M, Masai E
  Title
Uncovering the protocatechuate 2,3-cleavage pathway genes.
  Journal
J. Bacteriol. 191 (2009) 6758-68.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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