KEGG   ENZYME: 1.2.1.87Help
Entry
EC 1.2.1.87                 Enzyme                                 

Name
propanal dehydrogenase (CoA-propanoylating);
BphJ
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
propanal:NAD+ oxidoreductase (CoA-propanoylating)
Reaction(IUBMB)
propanal + CoA + NAD+ = propanoyl-CoA + NADH + H+ [RN:R09097]
Reaction(KEGG)
R09097;
(other) R01172
Show
Substrate
propanal [CPD:C00479];
CoA [CPD:C00010];
NAD+ [CPD:C00003]
Product
propanoyl-CoA [CPD:C00100];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme forms a bifunctional complex with EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase, with a tight channel connecting the two subunits [1,2,3]. Also acts, more slowly, on glycolaldehyde and butanal. In Pseudomonas species the enzyme forms a bifunctional complex with EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). NADP+ can replace NAD+ with a much slower rate [3].
History
EC 1.2.1.87 created 2013
Pathway
Xylene degradation
Propanoate metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K13922  
propionaldehyde dehydrogenase
K18366  
acetaldehyde/propanal dehydrogenase
Genes
ECG: 
ECC: 
ECV: 
ECW: 
ECQ: 
EUM: 
ECZ: 
ELN: 
ELF: 
EFE: 
STY: 
STY2256(pduP)
STT: 
t0823(pduP)
SEX: 
SENT: 
STM: 
STM2051(pduP)
SEO: 
SEV: 
SEY: 
SEM: 
SEJ: 
SEB: 
SEF: 
SETU: 
SETC: 
SEEN: 
SENR: 
SEND: 
SENI: 
SPT: 
SPA0820(pduP)
SEK: 
SPQ: 
SEI: 
SPC_1663(pduP)
SEC: 
SC2059(pduP)
SEH: 
SHB: 
SENH: 
SEEH: 
SEE: 
SENN: 
SEW: 
SEA: 
SENS: 
SED: 
SEG: 
SG2080(pduP)
SEL: 
SPUL_0849(pduP)
SEGA: 
SET: 
SEN2049(pduP)
SENJ: 
SEEC: 
SEEB: 
SEEP: 
SENB: 
BN855_21360(SBOV21111)
SENE: 
SES: 
YEN: 
YE2741(pduP)
YEP: 
YEY: 
SSN: 
SSON_2071(pduP)
SSJ: 
PWA: 
PEC: 
SOD: 
Sant_2129(eutE)
ESC: 
KPN: 
KPN_03216(pduP)
KPU: 
KP1_4485(pduP)
KPM: 
KPP: 
KPK: 
KPH: 
KPZ: 
KPV: 
KPW: 
KPY: 
KPG: 
KPQ: 
KPT: 
KPE: 
KPK_0899(pduP)
KPO: 
KPR: 
KPR_1818(pduP)
KPJ: 
KPI: 
KPA: 
KPS: 
KPX: 
PMK1_00697(adhE_2)
KPB: 
KVA: 
KOX: 
KOE: 
KOY: 
KOK: 
KOM: 
CKO: 
CRO: 
ROD_21371(pduP)
CFD: 
ROR: 
PSD: 
VEJ: 
PPI: 
ND085(nahO)
PPUT: 
PPUN: 
PP4_27270(mhpF)
PPUU: 
PSC: 
PSTU: 
PRE: 
PKC: 
PKB_4238(nahO)
PALK: 
AVN: 
AVL: 
AVD: 
SPC: 
SPL: 
SHW: 
SHL: 
SWD: 
PHA: 
PSHAa2142(mhpF)
TTU: 
CYQ: 
CZA: 
AEH: 
MMW: 
TAU: 
GPB: 
RPI: 
RPF: 
REH: 
CNC: 
RME: 
Rmet_1320(mhpF)
CTI: 
BVI: 
BUR: 
BCJ: 
BCAM1614(mhpF)
BCEN: 
BCT: 
BCED: 
BXE: 
Bxe_C1188(bphJ)
BXB: 
PPK: 
PRB: 
AXY: 
CDN: 
RFR: 
PNA: 
AJS: 
VEI: 
CTT: 
CTES: 
ADN: 
ADK: 
MPT: 
LCH: 
AZO: 
azo1856(lapF) azo1973(mhpF) azo2432(nahO)
DAR: 
TMZ: 
ARC: 
RPC: 
RCP: 
NPP: 
SJP: 
RRU: 
RRF: 
PGV: 
GTH: 
GMC: 
BSE: 
LMO: 
LMF: 
LMH: 
LMC: 
LMN: 
LMY: 
LMT: 
LMG: 
LMS: 
LMJ: 
LMQ: 
LMM7_1171(pduP)
LML: 
LMP: 
LMW: 
LMX: 
LMZ: 
LMON: 
LMOC: 
LMOS: 
LMOO: 
LMOY: 
LMOT: 
LMOA: 
LMOL: 
LMOG: 
LMOE: 
LMOB: 
LMOJ: 
LMOZ: 
LMOD: 
LMOW: 
LMOX: 
LMOQ: 
LMR: 
LMOK: 
LMV: 
LMOM: 
LIN: 
LWE: 
lwe1123(pduP)
LSG: 
lse_1043(pduP)
LIV: 
LII: 
LIW: 
LIA: 
LIO: 
LBR: 
LBK: 
LRE: 
LRF: 
LRU: 
PCE: 
PECL_1370(pduP)
CBK: 
CBT: 
CBE: 
CBZ: 
CSR: 
CSB: 
RUM: 
ROB: 
CPY: 
CSH: 
CSO: 
CST: 
TJR: 
ELM: 
AWO: 
OVA: 
TEX: 
THX: 
TOC: 
TTO: 
TXY: 
TSH: 
MAS: 
HAS: 
PUF: 
PAC: 
PAK: 
PAV: 
PAX: 
PAZ: 
PAW: 
PAD: 
PCN: 
PACC: 
PACH: 
PACN: 
PFR: 
PPC: 
PBO: 
PRA: 
BIP: 
FUS: 
IPO: 
STR: 
TLI: 
AMO: 
SBR: 
 » show all
Taxonomy
Reference
1  [PMID:19476337]
  Authors
Baker P, Pan D, Carere J, Rossi A, Wang W, Seah SY
  Title
Characterization of an aldolase-dehydrogenase complex that exhibits substrate channeling in the polychlorinated biphenyls degradation pathway.
  Journal
Biochemistry. 48 (2009) 6551-8.
  Sequence
[bxe:Bxe_C1188]
Reference
2  [PMID:21838275]
  Authors
Carere J, Baker P, Seah SY
  Title
Investigating the molecular determinants for substrate channeling in BphI-BphJ, an aldolase-dehydrogenase complex from the polychlorinated biphenyls degradation  pathway.
  Journal
Biochemistry. 50 (2011) 8407-16.
  Sequence
[bxe:Bxe_C1188]
Reference
3  [PMID:22316175]
  Authors
Baker P, Hillis C, Carere J, Seah SY
  Title
Protein-protein interactions and substrate channeling in orthologous and chimeric aldolase-dehydrogenase complexes.
  Journal
Biochemistry. 51 (2012) 1942-52.
  Sequence
[ttj:TTHB247]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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