KEGG   ENZYME: 1.2.1.89Help
Entry
EC 1.2.1.89                 Enzyme                                 

Name
D-glyceraldehyde dehydrogenase (NADP+);
glyceraldehyde dehydrogenase;
GADH
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-glyceraldehyde:NADP+ oxidoreductase
Reaction(IUBMB)
D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH + H+ [RN:R10615]
Reaction(KEGG)
Substrate
D-glyceraldehyde [CPD:C00577];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
D-glycerate [CPD:C00258];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from the archaea Thermoplasma acidophilum and Picrophilus torridus is involved in the non-phosphorylative Entner-Doudoroff pathway. cf. EC 1.2.99.8, glyceraldehyde dehydrogenase (FAD-containing).
History
EC 1.2.1.89 created 2014
Pathway
Pentose phosphate pathway
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K18128  
D-glyceraldehyde dehydrogenase (NADP+)
Genes
TAC: 
TVO: 
TVG1076124(TVG1076124)
PTO: 
FAC: 
AHO: 
Taxonomy
Reference
1  [PMID:16566751]
  Authors
Jung JH, Lee SB
  Title
Identification and characterization of Thermoplasma acidophilum glyceraldehyde dehydrogenase: a new class of NADP+-specific aldehyde dehydrogenase.
  Journal
Biochem. J. 397 (2006) 131-8.
  Sequence
[tac:Ta0809]
Reference
2  [PMID:16458304]
  Authors
Reher M, Schonheit P.
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS. Lett. 580 (2006) 1198-204.
  Sequence
[pto:PTO0332] [tac:Ta0809]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system