KEGG   ENZYME: 1.2.2.4Help
Entry
EC 1.2.2.4                  Enzyme                                 

Name
carbon-monoxide dehydrogenase (cytochrome b-561);
carbon monoxide oxidase;
carbon monoxide oxygenase (cytochrome b-561);
carbon monoxide:methylene blue oxidoreductase;
CO dehydrogenase;
carbon-monoxide dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
carbon monoxide,water:cytochrome b-561 oxidoreductase
Reaction(IUBMB)
CO + H2O + 2 ferricytochrome b-561 = CO2 + 2 H+ + 2 ferrocytochrome b-561 [RN:R04698]
Reaction(KEGG)
R04698;
(other) R00276
Show
Substrate
CO [CPD:C00237];
H2O [CPD:C00001];
ferricytochrome b-561 [CPD:C05305]
Product
CO2 [CPD:C00011];
H+ [CPD:C00080];
ferrocytochrome b-561 [CPD:C05183]
Comment
Contains molybdopterin cytosine dinucleotide, FAD and [2Fe-2S]-clusters. Oxygen, methylene blue and iodonitrotetrazolium chloride can act as nonphysiological electron acceptors.
History
EC 1.2.2.4 created 1999 (EC 1.2.3.10 created 1990, incorporated 2003), modified 2003
Reference
1
  Authors
Meyer, O., Jacobitz, S. and Kruger, B.
  Title
Biochemistry and physiology of aerobic carbon monoxide-utilizing bacteria.
  Journal
FEMS Microbiol. Rev. 39 (1986) 161-179.
Reference
2  [PMID:2808305]
  Authors
Jacobitz S, Meyer O.
  Title
Removal of CO dehydrogenase from Pseudomonas carboxydovorans cytoplasmic membranes, rebinding of CO dehydrogenase to depleted membranes, and restoration of respiratory activities.
  Journal
J. Bacteriol. 171 (1989) 6294-9.
  Organism
Pseudomonas carboxydovorans
Reference
3  [PMID:7354006]
  Authors
Meyer O, Schlegel HG.
  Title
Carbon monoxide:methylene blue oxidoreductase from Pseudomonas carboxydovorans.
  Journal
J. Bacteriol. 141 (1980) 74-80.
  Organism
Pseudomonas carboxydovorans
Reference
4  [PMID:10430865]
  Authors
Dobbek H, Gremer L, Meyer O, Huber R.
  Title
Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 8884-9.
  Organism
Oligotropha carboxidovorans
Reference
5  [PMID:10966817]
  Authors
Hanzelmann P, Dobbek H, Gremer L, Huber R, Meyer O.
  Title
The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase.
  Journal
J. Mol. Biol. 301 (2000) 1221-35.
  Organism
Hydrogenophaga pseudoflava
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
395639-79-9

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